20235-78-3

• 常用中文名：2-硫代尿苷
• 常用英文名：thiouridine
• CAS号：20235-78-3
• 分子式：C₉H₁₂N₂O₅S
• 分子量：260.267
• 相关类别： 生物化工 核苷类药物 核苷中间体
• 发布时间：2018-09-21 18:52:49
• 更新时间：2024-01-02 21:37:35
• 2-Thiouridine (s2U) is a modified nucleobase found in tRNAs that is known to stabilize U:A pairs and modestly destabilize U:G wobble pairs.

名称

• 中文名: 2-硫代尿苷
• 英文名: 2-Thiouridine
• 英文别名: 1-(β-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone; 4(1H)-Pyrimidinone, 2,3-dihydro-1-β-D-ribofuranosyl-2-thioxo-; 2-Thiouridine; 2-thiouridine—; thiouridine; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one

物化性质

• 密度: 1.7±0.1 g/cm3
• 熔点: 216-218ºC
• 分子式: C₉H₁₂N₂O₅S
• 分子量: 260.267
• 精确质量: 260.046692
• PSA: 139.80000
• LogP: -0.96
• 外观性状: 白色固体
• 折射率: 1.733
• 储存条件: Refrigerator

合成路线

21052-18-6 ~90% 20235-78-3

文献：El-Tayeb, Ali; Qi, Aidong; Mueller, Christa E. Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7076 - 7087

6974-32-9 ~85% 20235-78-3

文献：Sierzputowska-Gracz; Sochacka; Malkiewicz; Kuo; Gehrke; Agris Journal of the American Chemical Society, 1987 , vol. 109, # 23 p. 7171 - 7177

25030-30-2 ~65% 20235-78-3

文献：Robin, Aelig; Julienne, Karine; Meslin, Jean-Claude; Deniaud, David European Journal of Organic Chemistry, 2006 , # 3 p. 634 - 643

627812-08-2 ~% 20235-78-3

文献：European Journal of Organic Chemistry, , # 3 p. 634 - 643

6984-55-0 ~% 20235-78-3

文献：Journal of the Chemical Society, , p. 3028,3033

7408-41-5 ~% 20235-78-3

文献：Journal of the Chemical Society, , p. 2294,2297

53337-88-5 ~% 13957-31-8 20235-78-3

文献：Journal of Heterocyclic Chemistry, , vol. 17, p. 1601 - 1602

59495-20-4 ~% 13957-31-8 20235-78-3

文献：Journal of Heterocyclic Chemistry, , vol. 17, p. 1601 - 1602

3868-21-1 ~% 20235-78-3

文献：Journal of the Chemical Society, , p. 3028,3033

上下游产品

上游产品  7
21052-18-6 6974-32-9 25030-30-2 627812-08-2
7408-41-5 59495-20-4 3868-21-1
下游产品  3
58-96-8 29123-25-9 35763-29-2