924663-38-7

• 常用中文名：雷贝拉唑N-氧化物
• 常用英文名：Rabeprazole N-oxide
• CAS号：924663-38-7
• 分子式：C₁₈H₂₁N₃O₄S
• 分子量：375.442
• 发布时间：2018-09-21 07:04:50
• 更新时间：2026-07-17 15:13:16

名称

• 中文名: 雷贝拉唑N-氧化物
• 英文名: 2-[[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-1-ium-2-yl]methylsulfinyl]-1H-benzimidazole
• 中文别名: 雷贝拉唑氮氧化物; 雷贝拉唑氮氧化合物 标准品; 雷贝拉唑相关化合物B; 雷贝拉唑杂质1(雷贝拉唑杂质D); 雷贝拉唑杂质D; 雷贝拉唑相关物质B 标准品; 2-(((((1H-苯并[D]咪唑-2-基]亚磺酰基)甲基]甲基] -4-(3-甲氧基丙氧基)-3-甲基吡啶1-氧化物(雷贝拉唑杂质); 雷贝拉唑相关物质B; 雷贝拉唑EP杂质D; 雷贝拉唑 N-氧化物; 雷贝拉唑钠杂质B; 雷贝拉唑钠杂质D; 雷贝拉唑杂质B D
• 英文别名: 2-[[[1-Oxide-4-(3-methoxypropoxy)-3; Rabrazole Related Compound B (2-{[(1H-benzo[d]imidazol-2-yl)sulfinyl]methyl}-4-(3-methoxypropoxy); Rabrazole impurity 2/Rabrazole Impurity D/2-(((1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide; Rabrazole Impurity D Rabrazole Related Compound B , Rabrazole N-Oxide; 2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-1-OXIDO-PYRIDIN-2-YL]METHYL]SULFINYL]-1H-BENZO[D]IMIDAZOLE; 2-[(4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methylsulfinyl]-1H-benzoimidazole; 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]; Rabrazole IMpurity-N-Oxide; Rabrazole Related Compound B (15 mg) (2-{[(1H-benzo[d]imidazol-2-yl)sulfinyl]methyl}-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide); Rabrazole Related CoMpound B; Rabrazole Imp D; Rabrazole Related Compound D; 2-(((1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide (Rabrazole Impurity）; Rabrazolesodium Impurity D; 2-[[[4-(3-Methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole; Rabrazole Impurity D; Rabeprazole N-Oxide; Rabrazole Impurity 1（Rabrazole Impurity D）; 2-[([4-(3-methoxypropoxy)-3-methyl-2-pyridinyl-1-oxide]methyl)-sulfinyl]-1H-benzimidazole; Rabrazole sodium Impurity B; 2-[[[4-(3-Methoxypropoxy)-3-Methyl-1-oxido-2-pyridinyl]Methyl]sulfinyl]; 2-({[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole; Rabeprazole Impurity 1; 2-[4-(3-methoxypropoxy)-3-methyl-1-oxypyridin-2-yl-methylsulfinyl]-1H-benzimidazole; 2-{[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-2-yl]methylsulfinyl}-1H-benzoimidazole; Rabrazole Impurity D/ Rabrazole Related Compound B (Rabrazole N-Oxide); Rabrazole N-Oxide Impurity; Rabrazole Impurity E (Methoxyanalouge); Rabrazole-6; 2-[[[1-Oxide-4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole; 2-(((4-(3-Methoxypropoxy)-3-methyl-1-oxopyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole; UNII:17Q1V00385; 2-[[[4-[3-methoxypropoxy]-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H-benzimidazole N-oxide; Rabrazole IMpurity A; Rabrazole N-Oxide; Rabrazole Impurity D (N-Oxide)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 699.3±65.0 °C at 760 mmHg
• 分子式: C₁₈H₂₁N₃O₄S
• 分子量: 375.442
• 闪点: 376.7±34.3 °C
• 精确质量: 375.125275
• PSA: 109.72000
• LogP: -0.23
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.648

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

924663-40-1 ~35% 924663-38-7

文献：Radl, Stanislav; Klecan, Ondrej; Havlicek, Jaroslav Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1447 - 1453

924663-39-8 ~% 924663-38-7

文献：Synthetic Communications, , vol. 37, # 17 p. 2861 - 2868

上下游产品

上游产品  1
924663-40-1
下游产品  1
117976-89-3