55102-44-8

• 常用中文名：波呋莫司汀
• 常用英文名：Bofumustine
• CAS号：55102-44-8
• 分子式：C₁₈H₂₁ClN₄O₉
• 分子量：472.83400
• 相关类别： 原料药 抗肿瘤药 烷化剂类抗肿瘤药
• 发布时间：2018-02-16 08:00:00
• 更新时间：2026-07-16 19:51:59

名称

• 中文名: 波呋莫司汀
• 英文名: Urea, N-(2-chloroethyl)-N'-[2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitroso
• 英文别名: Bofumustine //BP; 1-(2-Chloroethyl)-3-[5-O-(p-nitrobenzoyl)-2-O,3-O-isopropylidene-D-ribofuranosyl]-1-nitrosourea; Urea, N-(2-chloroethyl)-N'-[2,3-o-(1-methylethylidene)-5-o-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitroso; N-(2-Chloroethyl)-N'-[2-O,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitrosourea; ICIG-1105; Nsc279194

物化性质

• 密度: 1.61g/cm3
• 沸点: 124.5°C (rough estimate)
• 熔点: 101.5°C
• 分子式: C₁₈H₂₁ClN₄O₉
• 分子量: 472.83400
• 精确质量: 472.10000
• PSA: 161.58000
• LogP: 2.84250
• 折射率: 1.647

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YS5079000 CHEMICAL NAME : Urea, 1-(2-chloroethyl)-1-nitroso-3-ribofuranosyl-, 5'-(p-nitrobenzoate), 2',3'-cyclic acetal with acetone CAS REGISTRY NUMBER : 55102-44-8 LAST UPDATED : 199410 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H21-Cl-N4-O9 MOLECULAR WEIGHT : 472.88 WISWESSER LINE NOTATION : T55 BO DO GOTJ C1 C1 FMVNNO&2G H1OVR DNW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 2 mg/L REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,229,1981

合成路线

51172-55-5 122-04-3 96408-95-6 ~% 55102-44-8

文献：Montero; Leydet; Messiez-Munoz; et al. European Journal of Medicinal Chemistry, 1984 , vol. 19, # 6 p. 512 - 518

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