486460-00-8

• 常用中文名：(3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸
• 常用英文名：Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
• CAS号：486460-00-8
• 分子式：C₁₅H₁₈F₃NO₄
• 分子量：333.303
• 发布时间：2018-12-21 23:42:33
• 更新时间：2026-07-01 00:12:49
• 西他列汀中间体

名称

• 中文名: (3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸
• 英文名: Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
• 中文别名: (3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸(西格列汀中间体); 西他列汀中间体BOC 丁酸; (3R)-N-叔丁氧羟基-3-氨基-4-(2,4,5-三氟苯基)丁酸; 西他列汀-BOC丁酸 BOC-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸; 西格列汀 N-叔丁氧羰基羧酸杂质; (3R)-3-叔丁氧碳基胺基-4-(2,4,5-三氟苯基)-丁酸; BOC-丁酸; [[(1,1-二甲基乙氧基)羰基]氨基] -2,4,5-三氟 - (R) - 苯丁酸; (R)-3-叔丁氧羰基氨基-4-(2,4,5-三氟苯基)丁酸,西它列汀中间体; (R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸; 西他列汀-BOC酸; Boc-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸; BOC-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸; (3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸(磷酸西他列汀中间体); (R)-西他列汀 N-BOC-ACID杂质; 西他列汀杂质78; (R)-N-BOC-3-氨基-4-(2,4,5-三氟苯基)丁酸; 西他列汀杂质58; 西格列汀杂质 15; 西他列汀杂质19; (3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸(西他列汀中间体); 西格杂质31; 西他列汀-BOC丁酸; R) -3-((叔丁氧羰基)氨基)-4-(2,4,5-三氟苯基)丁酸; (R)-N-BOC-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACIDBOC-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸[DMF NO. 027115]US 8,278,486 B2,OCT 2ND; 西他列汀杂质19((R)-西他列汀N-BOC-酸杂质); 西格列汀中间体; (3R)-N-BOC-3-氨基-4-(2,4,5-三氟苯基)-丁酸; 西他列汀中间体1; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY BOC-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸; 西格列汀杂质78; OC-(R)-3-氨基-4-(2,4,5-三氟苯基)丁酸; 磷酸西他列汀中间体B; 磷酸西格列汀杂质19
• 英文别名: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid; Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate; β-Alanine, N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-, ethyl ester; Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alaninate; (βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid; Sitagliptin N-BOC Cboxylic acid Impurity; Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid; 4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione; BOC-(R)-3-AMINO-4-(2; (3R)-N-(TERT-BUTOXYCBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU; Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR); ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate; N-Boc Sitagliptin Acid Impurity; (Tert-Butoxy)carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid; (3R)-3-[(2-methylpropan-2-yl)oxycbonylamino]-4-(2,4,5-trifluorophenyl) butanoic acid; (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-(2,4,5-trifluorophenyl)butanoic acid; Sitagliptin Impurity 78; (R)-Sitagliptin N-Boc-Acid IMpurity; BOC- Butanoic Acid; 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionic Acid Ethyl Ester; (3R)-N-(TERT-BUTOXYCBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID; (3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid; (3R) - N - (tert butoxycbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid; (3R)-N-Boc-3-amin; 3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide; (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid; Sitagliptin Impurity 19 (R)-3-((tert-butoxycbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid; (3R)-3-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-(2,4,5-trifluorophenyl)butanoic acid; (R)-3-(Tert-Butoxycbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY; Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid); Sitagliptin Intermediate 1; ALA002; Pecoxib SodiuM API; Sitagliptin Imp-1(sitagliptin Impurity-A); (R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid; (3R)-N-(tert-Butoxycbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]; (R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic; ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propanoate; Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate; Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid; ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propionate; (3R)-N-(tert-Butoxycbonyl)-3-amino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid); (3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid; Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-β-alaninate; Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]amino]-2,4,5-trifluoro-,(bR); BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid; Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci; Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid; Sitagliptin Acid Boc Impurity (Impurity A); Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity); Sitagliptin Impurity 19; Sitagliptin interMediate; Sitagliptin interMediateB; 3(R)-tert-ButoxycbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid; 5-TRIFLUORO-PHENYL)-BUTYRIC ACID; 4-(6-{[(tert-butoxy)carbonyl]amino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid; Sitagliptin Impurity 15; [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid; (R)-3-(Boc-amino)-4-(2,4,5-trifluorophenyl)butanoic acid; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH; (R)-3-((tert-Butoxycbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid; (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-; trifluorophenyl)butanoic Acid; (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid; Sitagliptin N-BOC Cboxylic Acid; (3R)-3-((1,1-DIMETHYLETHOXYCBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID; [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be; [[(1,1-diMethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebuta; (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid; SITAGLIPTIN CAS 654-0 INTERMEDIATES; 3-[(3-amino-4-methylamino-benzoyl)pyridin-2-yl-amino]-propionic acid ethyl ester; Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID; (R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid; ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 443.1±45.0 °C at 760 mmHg
• 分子式: C₁₅H₁₈F₃NO₄
• 分子量: 333.303
• 闪点: 221.8±28.7 °C
• 精确质量: 333.118805
• PSA: 75.63000
• LogP: 3.35
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.494
• 储存条件: 室温

安全

• 海关编码: 2942000000

合成路线

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海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%