103500-22-7

• 常用中文名：N-[1-(羟甲基)环丙基]氨基甲酸苯甲酯
• 常用英文名：N-[1-(Hydroxymethyl)cyclopropyl]carbamic acid phenylmethyl ester
• CAS号：103500-22-7
• 分子式：C₁₂H₁₅NO₃
• 分子量：221.252
• 发布时间：2018-04-12 08:00:00
• 更新时间：2026-07-15 20:32:27

名称

• 中文名: Cbz-1-氨基环丙烷甲醇
• 英文名: Benzyl (1-(hydroxymethyl)cyclopropyl)carbamate
• 中文别名: 1-羟甲基-1-(苄氧甲酰胺基)环丙烷; 安洛替尼杂质2; 安洛替尼杂质3; N- [1-(羟甲基)环丙基]氨基甲酸苄酯; 1-(羟甲基)环丙基)氨基甲酸苄酯; 苄基(1-(羟甲基)环丙基)氨基甲酸酯; 安罗替尼杂质3; N-CBZ-1-(羟甲基)环丙胺; N-[1-(羟甲基)环丙基]氨基甲酸苯甲酯N-[1-(HYDROXYMETHYL)CYCLOPROPYL]CBAMIC ACID PHENYLMETHYL ESTER; CBZ-1-氨基环丙烷甲醇; 1-羟甲基-1-(苄氧甲酰胺基)环丙基
• 英文别名: AnlotinibImpurity3; Anlotinib Impurity; N-cbz-1-amino-cyclopropanemethanol; Anlotinib Impurity 2; benzyl N‐[1‐(hydroxymethyl)cyclopropyl]cbamate; 1-(Cbz-amino)cyclopropanemethanol; N-[1-(Hydroxymethyl)Cyclopropyl]Cbamic Acid Phenylmethyl E; Anlotinib Impurity 6; Allotinib Impurity 3; CbaMic acid, [1-(hydroxyMethyl)cyclopropyl]-, phenylMethyl ester; N-(Benzyloxycbonyl)-1-(hydroxymethyl)cyclopropanamine; N-[1-(Hydroxymethyl)cyclopropyl]cbamic acid phenylmethyl ester; Benzyl (1-(hydroxymethyl); benzyl 1-(hydroxymethyl)cyclopropylcbamate; 1- hydroxymethyl -1- (benzyloxyformamido) cyclopropane; Carbamic acid, N-​[1-​(hydroxymethyl)​cyclopropyl]​-​, phenylmethyl ester; CbaMic acid, N-[1-(hydroxyMethyl)cyclopropyl]-, phenylMethyl ester; [1-(Hydroxymethyl)cyclopropyl]-cbamic acid phenylmethyl ester; Benzyl [1-(hydroxymethyl)cyclopropyl]carbamate; Carbamic acid, N-[1-(hydroxymethyl)cyclopropyl]-, phenylmethyl ester; Cbz-1-AMinocyclopropylMethanol; N-Cbz-1-(hydroxymethyl)cyclopropylamine

物化性质

• 密度: 1.23
• 沸点: 393 ºC
• 分子式: C₁₂H₁₅NO₃
• 分子量: 221.252
• 闪点: 192 ºC
• 精确质量: 221.105194
• PSA: 62.05000
• LogP: 1.11
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 室温

安全

• 海关编码: 2924299090

合成路线

84677-06-5 ~94% 103500-22-7

文献：WO2008/64157 A1, ; Page/Page column 103 ;

85452-41-1 ~89% 103500-22-7

文献：Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1840 - 1846

85452-41-1 ~44% 103500-23-8 103500-22-7

文献：Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1840 - 1846

501-53-1 ~% 103500-22-7

文献：Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1840 - 1846

上下游产品

上游产品  3
84677-06-5 85452-41-1 501-53-1
下游产品  0

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%