1246616-73-8

• 常用中文名：(S)-7-羟基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷
• 常用英文名：(4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
• CAS号：1246616-73-8
• 分子式：C₁₃H₁₄N₂O₆
• 分子量：294.26000
• 发布时间：2016-11-23 13:38:04
• 更新时间：2026-09-14 16:31:08

名称

• 中文名: (S)-7-羟基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3] 噁嗪烷
• 英文名: (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
• 中文别名: (4R,12AS)-7-羟基-4-甲基-6,8-二氧代-3,4,6,8,12,12A-六氢-2H-吡啶并[1',2':4,5]吡嗪并[ 2,1-B][1,3]噁嗪-9-羧酸; 度鲁特韦杂质25; (4R,12AS)-3,4,6,8,12,12A-六氢-7-羟基-4-甲基-6,8-二氧代-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]恶嗪-9-羧酸; 度鲁特韦杂质25 DOLUTEAVIR IMPURITY 25; 度鲁特韦中间体2; 度鲁特韦杂质F; 多替拉韦杂质9; 度鲁特韦杂质62; 多替拉韦杂质72
• 英文别名: (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-c; KA8Zea9qpd; (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic acid; (4R,12aS)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cbox; Galactose Impurity 4 (Galactose Impurity D); Doluteavir impurity 7/(4R,12As)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic Acid; (4r，12As)-7-hydroxy-4-methyl-6，8-dioxo-3，4，6，8，12，12a-hexahydro-2h-pyrido[1'，2':4，5]pyrazino[2，1-b][1，3]oxazine-9-cboxylic acid; 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic acid, 3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS); (4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic acid; Doluteavir Intermediate2; Doluteavir Impurity F; Durutevir Impurity 25; (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1; (S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic acid (Related Reference); Dotiravir Impurity 9; Doulteavir Imp F(Tri cyclic impurity); Doluteavir Impurity 62; Doluteavir Intermediates1; (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-cboxylic acid; (4R,12aS)-7-Hydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-cboxylic acid; Doulteavir 4-F Impurity G; Dolutegravir Intermediate2

物化性质

• 分子式: C₁₃H₁₄N₂O₆
• 分子量: 294.26000
• 精确质量: 294.08500
• PSA: 109.07000

合成路线

134653-70-6 ~% 1246616-73-8

文献：Sumino, Yukihito; Okamoto, Kazuya; Masui, Moriyasu; Akiyama, Toshiyuki Patent:   US2012/22251 A1, 2012 ;

1246616-74-9 ~% 1246616-73-8

文献：Sumino, Yukihito; Okamoto, Kazuya; Masui, Moriyasu; Akiyama, Toshiyuki Patent:   US2012/22251 A1, 2012 ;

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