473927-63-8

• 常用中文名：(2Z)-氯[(4-甲氧基苯基)亚肼基]乙酸乙酯
• 常用英文名：ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
• CAS号：473927-63-8
• 分子式：C₁₁H₁₃ClN₂O₃
• 分子量：256.685
• 发布时间：2018-06-27 13:04:19
• 更新时间：2025-08-21 11:53:11

名称

• 中文名: (2Z)-氯[(4-甲氧基苯基)亚肼基]乙酸乙酯
• 英文名: ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
• 中文别名: (2Z)-2-氯-2-[2-(4-甲氧基苯基)肼亚基]乙酸乙酯; 阿皮沙班杂质O; 2-氯-2-(2-(4-甲氧基苯基)腙基)乙酸乙酯; 阿哌沙班杂质O; (2Z)-氯[(4-甲氧基苯基)亚肼基]乙酸乙酯(阿哌沙班中间体); 阿哌沙班杂质APX-YJZ; (2Z)-氯[(4-甲氧基苯基)亚肼基]乙酸乙酯Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
• 英文别名: Ethyl(2Z)-2-chloro-2-((4-methoxyphenyl)hydrazono)acetate; Apixaban I; Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]acetate; (2Z)-Chloro[(4-methoxyphenyl)hydrazono]aceticacidethylester; Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate; Ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate; Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-, ethyl ester, (2Z); Apixaban int; (2Z)-2-Chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetic acid ethyl ester; Acetic acid, chloro[(4-Methoxyphenyl)hydrazono]-, ethyl ester, (2Z); Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl este; Apixaban Impurity O; Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetateQ: What is Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Q: What is the CAS Number of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate; ethyl (2Z)-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 349.0±44.0 °C at 760 mmHg
• 分子式: C₁₁H₁₃ClN₂O₃
• 分子量: 256.685
• 闪点: 164.8±28.4 °C
• 精确质量: 256.061462
• PSA: 59.92000
• LogP: 3.17
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.533
• 储存条件: 室温，干燥

合成路线

104-94-9 609-15-4 ~88% 473927-63-8

文献：Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexander, Richard S.; Smallwood, Angela; Wong, Paneras C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; He, Kan; Xin, Baomin; Wexler, Ruth R.; Lam, Patrick Y. S. Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5339 - 5356

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