91-79-2

• 常用中文名：西尼二胺
• 常用英文名：thenyldiamine
• CAS号：91-79-2
• 分子式：C₁₄H₁₉N₃S
• 分子量：261.38600
• 相关类别： 原料药 抗变态反应药 过敏反应介质阻滞剂
• 发布时间：2018-03-16 08:00:00
• 更新时间：2024-01-14 19:26:01

名称

• 中文名: 西尼二胺
• 英文名: N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-3-ylmethyl)ethane-1,2-diamine
• 英文别名: Tenildiamina [INN-Spanish]; Tenfidil; Thenyldiaminum [INN-Latin]; Thefanil; Thenyldiamine; Thenyldiamine (pharmaceutical); N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine; Thenfadil; Dethylandiamine; Thenyldiamin; N,N-Dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-aethylendiamin

物化性质

• 密度: 1.1388 (rough estimate)
• 沸点: 169-172ºC at 1.0 MM HG
• 分子式: C₁₄H₁₉N₃S
• 分子量: 261.38600
• 精确质量: 261.13000
• PSA: 47.61000
• LogP: 2.71130
• 折射率: nD20 1.5915

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UT1575000 CHEMICAL NAME : Pyridine, 2-((2-(dimethylamino)ethyl)-3-thenylamino)- CAS REGISTRY NUMBER : 91-79-2 BEILSTEIN REFERENCE NO. : 0221267 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C14-H19-N3-S MOLECULAR WEIGHT : 261.42 WISWESSER LINE NOTATION : T6NJ BN2N1&1&1- CT5SJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Gastrointestinal - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 30 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

合成路线

100523-84-0 ~% 91-79-2

文献：Campaigne; Bourgeois Journal of the American Chemical Society, 1954 , vol. 76, p. 2445

23826-72-4 ~% 91-79-2

文献：Campaigne; Bourgeois Journal of the American Chemical Society, 1954 , vol. 76, p. 2445

88-13-1 ~% 91-79-2

文献：Campaigne; Bourgeois Journal of the American Chemical Society, 1954 , vol. 76, p. 2445

34846-44-1 23826-72-4 ~% 91-79-2

文献：Campaigne; Le Suer Journal of the American Chemical Society, 1949 , vol. 71, p. 333