147027-10-9

• 常用中文名：5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯
• 常用英文名：(2R-CIS)-5-(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL)
• CAS号：147027-10-9
• 分子式：C₁₈H₂₇N₃O₄S
• 分子量：381.490
• 发布时间：2018-12-18 19:36:50
• 更新时间：2026-07-09 00:45:24

名称

• 中文名: 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯
• 英文名: (2R,5S)-L-Methyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
• 中文别名: 拉米夫定杂质45; 孟基胞嘧啶酯; 拉米夫定中间体(CME); (2R,5S)-(1R,2S,5R)-2-异丙基-5-甲基环己基 5-(4-氨基-2-羰基嘧啶-1(2H)-基)-1,3-氧硫杂戊环-2-羧酸酯; 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯(CME); (2R,5S)-拉米夫定杂质33; 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-(1,3)1,3-氧硫杂环戊-2-甲酸孟酯; (1R,2S,5R)-5-甲基-2-(1-甲基乙基)环己基(2R,5S)-5-(4-氨基-2-氧代-1,2-二氢嘧啶-1-基)-1,3-氧硫杂环己烷-2-羧酸酯(CME); 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸酯; 5S-(1-胞嘧啶)-1,3-氧硫杂环戊烷-2R-甲酸薄荷醇酯; 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸酯桶; 氧硫杂环戊烷-2-羧酸-L-薄荷酯; (2R,5R)-5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]-氧硫杂环戊-2-甲酸孟酯; 拉米夫定中间体; (1R,2S,5R)-2-异丙基-5-甲基环己基(2R,5S)-5-(4-氨基-2-氧代嘧啶-1(2H)-基)-1,3-氧硫杂环戊烷-2-甲酸酯; (2R,5R)-5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]氧硫杂环戊-2-羧酸,2S-异丙基-5R-甲基-1R-环己酯; 环己基酯; 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯(拉米夫定中间体); 恩曲他滨杂质24
• 英文别名: (2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl; (2R-CIS)-5-(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL) (CME); 2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; (2R,5S)-L-Menthyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-cboxylate; Menthyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-cboxylic acid; 5-methyl-2-(propan-2-yl)cyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxat; (1'R,2'S,5'R)-Menthyl-(2R,5S)-5-(4-Amino-2-Oxo-2H-Pyrimidin-1-yl)-[1,3]Oxathiolane-2-Caboxylicacid; (1R,2S,5R)-menthyl 5S-(cytosine-1-yl)-[1,3]-oxathiolane-2R-cboxylate (CME); (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-cboxylate; 5-(4-amino-2-oxo-1-pyrimidinyl)-1,3-oxathiolane-2-cboxylic acid (5-methyl-2-propan-2-ylcyclohexyl) ester; (2R.5S)-5- (4-amino-2-oxo-1(2H)-pyrimidin-1-yl) [1.3]oxathiolane-2-cboxylic acid(IR,2S,5R)-5-methyl-2 (1-methylethyD)cyclohexylester (CME); (2R,5S)-L-Methyl-5-(4-amino-2-oxo-1(2H)-pyriMidinyl)-1,3-oxathiolane-2-cboxylate; (2R-Cis)-4-Amino-1[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]-2(1H)-Pyrimidinone Salicylate Monohydrate (Cme); 1,3-Oxathiolane-2-cboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5S); (1R,2S,5R)-Menthyl-(2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-cboxylic acid; (2R-CIS)-4-AMINO-1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]-H-PHRIMIDIONE; (2R,5S)-Lamivudine Impurity 33; MFCD00869739; (2S.5R)-5-Cytosine-1-yl-[1,3]-oxathiolane -2-cboxylic acid menthyl ester (CME); Cytidine(CME); 2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; Emtricitabine Impurity 24; (2'R)-(CIS)-4-AMINO-1-[2-[2-CBOXYLMETHOLYL]-1,3-OXATHIOLAN-5-YL]-2-(1H)-PYRIMIDINONE; (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-cboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(CME); LamivudineIntermediate(CME); (2R,5S); (1R,2S,5R)-Menthyl-(2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid; Lamivudine Impurity 21; (5R)-2-Isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; (2S,5R)-5-Cytosine-1-yl-[1,3]-oxathiolane-2-cboxylic acid menthyl ester; Lamivudine Impurity 45; (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-cboxylate; 2S-isopropyl-5R-methyl-1R-cyclohexyl (2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-oxathiolane-2-cboxylate; (2R,5S)-((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyl) 5-(4-amino-2-oxopyriMidin-1(2H)-yl)-1,3-oxathiolane-2-cboxylate; (2R,5S)-5-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-cboxylic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathio; (1R,2S,5R)-MENTHYL-(2R,5S)-5-(4-AMINO-2-OXO-2H-5-FLUORO-PYRIMIDIN-1-YL)-[1,3]-OXATHIOLANE-2-CBOXYLIC ACID; 5(4-AMINO-2-OXO-PYRIMIDINYL-OXATHIOLANE- 2-CBOXYLIC ACID-ISOPROPYL-METHYL-CYCLO HEXYL ESTER; oxathiolane-2-cboxylic acid; (2R,5S)-L-Menthol-5-(4-amino-2-oxo-1(2H)-pyriMidinyl)-1,3-oxathiolane-2-cboxylate; (1R, 2S, 5R)-MENTHYL-5(S)-(CYTOSINE-1-YL)-1, 3-OXATHIOLANE-2(R)-CBOXYLIC ACID CYCLOHEXYL ESTER; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, 5-methyl-2-(1-methylethyl)cyclohexyl ester; (1R,2S,5R)-MENTHYL-(2R,5S)-5-(4-AMINO-2-OXO-2H-5-FLUORO-PYRIMIDIN-1-YL)-[1,3]-OXATHIOLANE-2-CBOXYLIC ACOID

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 525.0±60.0 °C at 760 mmHg
• 熔点: 203-210°C
• 分子式: C₁₈H₂₇N₃O₄S
• 分子量: 381.490
• 闪点: 271.3±32.9 °C
• 精确质量: 381.172241
• PSA: 121.74000
• LogP: 3.47
• 外观性状: 黄褐色固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.655
• 储存条件: -20°C Freezer

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