147687-17-0

• 常用中文名：3-(2-氯乙基)-2-甲基-9-苄氧基-4H-吡啶并[1,2A]嘧啶-4酮 (帕潘立酮)
• 常用英文名：9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one
• CAS号：147687-17-0
• 分子式：C₁₈H₁₇ClN₂O₂
• 分子量：328.793
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 乙基吡啶
• 发布时间：2018-12-04 12:36:43
• 更新时间：2026-06-30 14:30:41

名称

• 中文名: 3-(2-氯乙基)-2-甲基-9-苄氧基-4H-吡啶并[1,2A]嘧啶-4酮 (帕潘立酮)
• 英文名: 3-(2-chloroethyl)-2-methyl-9-phenylmethoxypyrido[1,2-a]pyrimidin-4-one
• 中文别名: 3-(2-氯乙基)-2-甲基-9-苄氧基-4H-吡啶并[1,2A]嘧啶-4酮 (帕潘立酮中间体); 帕利哌酮杂质02; 9-(苄氧基)-3-(2-氯乙基)-2-甲基-4H-吡啶[1,2-A]嘧啶-4-酮; 帕潘立酮杂质24; 帕利哌酮杂质ZY2; 3-(2-氯乙基)-2-甲基-9-苄氧基-4H-吡啶并[1,2A]嘧啶-4-酮; 3-(2-氯乙基)-2-甲基-9-(苯基甲氧基)-4H-吡啶并[1,2-A]嘧啶-4-酮; 帕利哌酮杂质; 帕潘立酮 N-1中; 帕利哌啶杂质4
• 英文别名: 4H-Pyrido[1,2-a]pyrimidin-4-one,3-(2-chloroethyl)-2-methyl-9-(phenylmethoxy); 9-(Benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; Paliperidone Impurity 1 (chlorobenzyloxy impurity); 9-Benzyloxy-3-(2-Chloroethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one; 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one ISO 9001：2015 REACH; 3-(2-chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidine-4-one; 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-(2-chloroethyl)-2-Methyl-9-(phenylMethoxy); 3-(2-chloroethyl)-2-methyl-9-(phenylmethoxy)-4H-pyrido[1,2-a]pyrimidin-4-one; Paliperidone-2; Paliperidone Impurity ZY2; 9-benzyloxy-3-(2-chloroethyl)-2-methylpyrido[1,2-a]pyrimidine-4-one; 9-Benzyloxy-3-(2-chloroethyl)-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one; Paliperidone impurity 18/3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one; 3-(2-chloroethyl)-2-Methyl-9-(phenylMethoxy); 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimid; 3-(2-Chloroethyl)-2-Methyl-9-(phenylMethoxy)-4H-pyrido[1,2-a]pyriMidin-4-one; 9-(Benzyloxy)-3-(2-chlorethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on; 4H-Pyrido[1; 9-benzyloxy-3-(2-chloroethyl)-2-methyl-pyrido[1,2-a]pyrimidin-4-one; Paliperidone Impurities14; Paliperidone N-1 Intermediate; 3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidin-4-one; 2-a]pyriMidin-4-one; 3-(2-chloroethyl)-9-benzyloxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one; 3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone); 9-benzyloxy-3-(2-chloro-ethyl)-2-methyl-pyrido[1,2-a]pyrimidin-4-one; Paliperidone Impurities111; 3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido- [1,2-a] pyrimidine-4-one; 3-(2-chloromethyl)-2-methyl-9-(phenylmethoxy)-4H-pyrido[1,2a]pyrimidine-4-one; 9-benzyloxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 9-Benxyloxy-3-(2-Chloroethyl)-2-methylpyrido[1,2-a]pyrimidine-4-one

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 505.0±60.0 °C at 760 mmHg
• 熔点: 140-142ºC
• 分子式: C₁₈H₁₇ClN₂O₂
• 分子量: 328.793
• 闪点: 259.2±32.9 °C
• 精确质量: 328.097870
• PSA: 43.60000
• LogP: 3.70
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.608
• 储存条件: Refrigerator

安全

• 海关编码: 2933990090

合成路线

517-23-7 24016-03-3 ~69% 147687-17-0

文献：ORCHID CHEMICALS and PHARMACEUTICALS LIMITED Patent: US2010/298566 A1, 2010 ; Location in patent: Page/Page column 6 ;

1008796-22-2 ~70% 147687-17-0

文献：NATCO PHARMA LIMITED Patent: WO2009/10988 A1, 2009 ; Location in patent: Page/Page column 13 ;

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%