522-00-9

• 常用中文名：乙丙嗪
• 常用英文名：Ethopropazine
• CAS号：522-00-9
• 分子式：C₁₉H₂₄N₂S
• 分子量：312.472
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-04-03 08:00:00
• 更新时间：2024-01-11 06:40:30

名称

• 中文名: 乙丙嗪
• 英文名: profenamine
• 中文别名: 普罗吩胺
• 英文别名: (S)-profenamine; Parsitan; Parsidol; Phenopropazine; ethopropazine; N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine; (2S)-N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine; Prophenamine; Prophenaminum; Profenamine; Profenaminum; Ethopromazine; profenaminum [INN_la]; 10H-Phenothiazine-10-ethanamine, N,N-diethyl-α-methyl-, (αS)-; Parkin

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 430.1±34.0 °C at 760 mmHg
• 熔点: 53-55°
• 分子式: C₁₉H₂₄N₂S
• 分子量: 312.472
• 闪点: 213.9±25.7 °C
• 精确质量: 312.166016
• PSA: 31.78000
• LogP: 5.84
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.599
• 储存条件: -20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SO4900000 CHEMICAL NAME : Phenothiazine, 10-(2-(diethylamino)propyl)- CAS REGISTRY NUMBER : 522-00-9 LAST UPDATED : 199706 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C19-H24-N2-S MOLECULAR WEIGHT : 312.51 WISWESSER LINE NOTATION : T C666 BN ISJ B1Y1&N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,41,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,293,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,41,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,41,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,41,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,41,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7007 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)