5942-95-0

• 常用中文名：卡匹帕明
• 常用英文名：carpipramine
• CAS号：5942-95-0
• 分子式：C₂₈H₃₈N₄O
• 分子量：446.62800
• 相关类别： 原料药 神经系统用药 抗抑郁、躁狂药
• 发布时间：2018-08-12 17:24:33
• 更新时间：2024-01-14 19:57:24

名称

• 中文名: 卡匹帕明
• 英文名: 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide
• 中文别名: 卡比咪嗪
• 英文别名: 1'-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-octahydro-[1,4']bipyridinyl-4'-carboxylic acid amide; EINECS 227-700-0; Carbadipimidine; Bay b 4343 b; Carpipramine (INN); Carpipramine; Carpipraminum [INN-Latin]; Carpipramina [INN-Spanish]

物化性质

• 密度: 1.143g/cm3
• 沸点: 637.1ºC at 760 mmHg
• 分子式: C₂₈H₃₈N₄O
• 分子量: 446.62800
• 闪点: 339.1ºC
• 精确质量: 446.30500
• PSA: 52.81000
• LogP: 4.76030
• 折射率: 1.598
• 储存条件: 库房低温通风干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HO0875000 CHEMICAL NAME : 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(4-piperidino-4-carbamoylpiperidin o)propyl)- CAS REGISTRY NUMBER : 5942-95-0 BEILSTEIN REFERENCE NO. : 0502521 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C28-H38-N4-O MOLECULAR WEIGHT : 446.70 WISWESSER LINE NOTATION : T C676 BN&T&J B3- AT6NTJ DVZ D- AT6NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1025 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 76 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 136 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,38,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,63,1972