66164-07-6

• 常用中文名：去甲盐酸洛哌丁胺
• 常用英文名：desmethyl loperamide
• CAS号：66164-07-6
• 分子式：C₂₈H₃₁ClN₂O₂
• 分子量：463.011
• 发布时间：2016-02-09 03:26:24
• 更新时间：2025-08-24 19:58:50

名称

• 中文名: 去甲盐酸洛哌丁胺
• 英文名: N-Desmethyl Loperamide
• 中文别名: N-去甲基洛派丁胺; N-脱甲基-洛哌丁胺; 乙腈中去甲盐酸洛哌丁胺; 去甲基洛哌丁胺; N-去甲基洛哌丁胺; 4-(4-氯苯基)-4-羟基-N-甲基-ALPHA,ALPHA-二苯基-1-哌啶丁酰胺; N-去甲洛哌丁; N-去甲基洛哌丁胺(洛哌丁胺杂质2)
• 英文别名: 4-(4-Chlorophenyl)-4-hydroxy-N-Methyl-α,α-diphenyl-1-piperidinebutanaMide; 4-(4-Chlorophenyl)-4-hydroxy-N-methyl-a,a-diphenyl-1-piperidinebutanamide; dLop; DESMETHYL LOPERAMIDE; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-N-methyl-2,2-diphenylbutanamide; Desmethylloperamide D5; Desmethyl loperamide HCl; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N-methyl-2,2-diphenylbutanamide; 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N-methyl-α,α-diphenyl; 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-methyl-2,2-diphenylbutanamide; Loperamide-N-desmethyl 100 μg/mL in Acetonitrile; N-Desmethyl Loperamid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 678.3±55.0 °C at 760 mmHg
• 熔点: 219-221ºC
• 分子式: C₂₈H₃₁ClN₂O₂
• 分子量: 463.011
• 闪点: 364.0±31.5 °C
• 精确质量: 462.207397
• PSA: 52.57000
• LogP: 3.71
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.603

安全

• 海关编码: 2933399090

合成路线

66164-06-5 74-88-4 ~3% 66164-07-6

文献：Lazarova, Neva; Zoghbi, Sami S.; Hong, Jinsoo; Seneca, Nicholas; Tuan, Ed; Gladding, Robert L.; Liow, Jeih-San; Taku, Andrew; Innis, Robert B.; Pike, Victor W. Journal of Medicinal Chemistry, 2008 , vol. 51, # 19 p. 6034 - 6043

37742-98-6 ~% 66164-07-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263

50650-44-7 ~% 66164-07-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263

37743-06-9 ~% 66164-07-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263

956-89-8 ~% 66164-07-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263

上下游产品

上游产品  5
66164-06-5 74-88-4 37742-98-6 37743-06-9
956-89-8
下游产品  0

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%