76129-15-2

• 常用中文名：Colchicine, 10-(benzylamino)-10-demethoxy-
• 常用英文名：Colchicine, 10-(benzylamino)-10-demethoxy-
• CAS号：76129-15-2
• 分子式：C₂₈H₃₀N₂O₅
• 分子量：474.54800
• 发布时间：2016-10-19 02:45:39
• 更新时间：2024-02-15 21:29:53

名称

• 英文名: Acetamide, N-[5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-[(phenylmethyl)amino]benzo[a]heptalen-7-yl]-, (S)
• 英文别名: N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-benzylamino-9-oxobenzo[a]heptalen-7-yl]acetamide; N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzo<a>heptalen-7-yl>-(S)-acetamide; 10-(Benzylamino)-10-demethoxycolchicine; N-((S)-10-Benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid; (S)-7-Acetylamino-10-benzylamino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-((S)-10-benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide; N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-10-benzylaminobenzo[a]heptalen-7-yl]acetamide

物化性质

• 密度: 1.25g/cm3
• 沸点: 794.2ºC at 760 mmHg
• 分子式: C₂₈H₃₀N₂O₅
• 分子量: 474.54800
• 闪点: 434.1ºC
• 精确质量: 474.21500
• PSA: 85.89000
• LogP: 4.93900
• 折射率: 1.622

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC8755000 CHEMICAL NAME : Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-((phe nylmethyl)amino)benzo (a) heptalen-7-yl)-, (S)- CAS REGISTRY NUMBER : 76129-15-2 BEILSTEIN REFERENCE NO. : 3185612 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C28-H30-N2-O5 MOLECULAR WEIGHT : 474.60 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 DO1 JMV1 NM1R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

合成路线

64-86-8 100-46-9 ~94% 76129-15-2

文献：Quinn, Frank R.; Beisler, John A. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 251 - 256

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