13256-32-1

• 常用中文名：Urea,N,N'-dimethyl-N'-nitroso-
• 常用英文名：Urea,N,N'-dimethyl-N'-nitroso-
• CAS号：13256-32-1
• 分子式：C₃H₇N₃O₂
• 分子量：117.10700
• 发布时间：2017-02-28 17:27:49
• 更新时间：2024-04-05 22:53:16

名称

• 英文名: 1,3-dimethyl-1-nitrosourea
• 英文别名: N,N'-Dimethylnitrosourea; 1,3 dimethyl 1 nitrosourea; N-nitroso-1,3-dimethylurea; Dimethylnitrosourea; 1,3-Dimethylnitrosourea; N-nitroso-N,N'-dimethylurea; 1,3-Dimethyl-N-nitrosourea; 1,2-Dimethyl-1-nitrosourea; Nitrosodimethylurea; N,N'-Dimethyl-N-nitrosourea; N-Nitrosodimethylurea

物化性质

• 密度: 1.25g/cm3
• 分子式: C₃H₇N₃O₂
• 分子量: 117.10700
• 精确质量: 117.05400
• PSA: 61.77000
• LogP: 0.32990
• 折射率: 1.505

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YT0350000 CHEMICAL NAME : Urea, 1,3-dimethyl-1-nitroso- CAS REGISTRY NUMBER : 13256-32-1 BEILSTEIN REFERENCE NO. : 1756842 LAST UPDATED : 199612 DATA ITEMS CITED : 22 MOLECULAR FORMULA : C3-H7-N3-O2 MOLECULAR WEIGHT : 117.13 WISWESSER LINE NOTATION : ONN1&VM1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1300 mg/kg/65W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 836 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 660 mg/kg/66W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 720 mg/kg/9W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 680 mg/kg/17W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 56222 mg/kg/30W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 20 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 10 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 50 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : DNA inhibition MUTATION DATA TYPE OF TEST : Host-mediated assay TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 100 mg/kg REFERENCE : EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 8(3),70,1986

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