269055-76-7

• 常用中文名：6-脱氨基-6-氯四维碱-13C3
• 常用英文名：4-[[5-BROMO-6-CHLORO-2-[(4-CYANOPHENYL)AMINO]-4-PYRIMIDINYL] OXY]-3,5-DIMETHYL-BENZONITRILE
• CAS号：269055-76-7
• 分子式：C₂₀H₁₃BrClN₅O
• 分子量：454.70700
• 发布时间：2016-06-27 23:45:53
• 更新时间：2024-01-23 14:17:41

名称

• 中文名: 6-脱氨基-6-氯四维碱-13C3
• 英文名: 4-[5-bromo-6-chloro-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
• 英文别名: 6-Desamino 6-Chloro Etravirine

物化性质

• 分子式: C₂₀H₁₃BrClN₅O
• 分子量: 454.70700
• 精确质量: 452.99900
• PSA: 94.62000
• LogP: 5.86156

合成路线

4198-90-7 269055-75-6 ~44% 269055-76-7

文献：TIBOTEC PHARMACEUTICALS LTD. Patent: WO2006/94930 A1, 2006 ; Location in patent: Page/Page column 19 ;

329187-59-9 ~% 269055-76-7

文献：Ludovici, Donald W.; De Corte, Bart L.; Kukla, Michael J.; Ye, Hong; Ho, Chih Y.; Lichtenstein, Mark A.; Kavash, Robert W.; Andries, Koen; De Bethune, Marie-Pierre; Azijn, Hilde; Pauwels, Rudi; Lewi, Paul J.; Heeres, Jan; Koymans, Lucien M.H.; De Jonge, Marc R.; Van Aken, Koen J.A.; Daeyaert, Frederik F.D.; Das, Kalyan; Arnold, Edward; Janssen, Paul A.J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2235 - 2239

374067-80-8 ~% 269055-76-7

文献：Ludovici, Donald W.; De Corte, Bart L.; Kukla, Michael J.; Ye, Hong; Ho, Chih Y.; Lichtenstein, Mark A.; Kavash, Robert W.; Andries, Koen; De Bethune, Marie-Pierre; Azijn, Hilde; Pauwels, Rudi; Lewi, Paul J.; Heeres, Jan; Koymans, Lucien M.H.; De Jonge, Marc R.; Van Aken, Koen J.A.; Daeyaert, Frederik F.D.; Das, Kalyan; Arnold, Edward; Janssen, Paul A.J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2235 - 2239

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