89268-62-2

• 常用中文名：法莫替丁相关化合物B
• 常用英文名：Famotidine Related Compound B
• CAS号：89268-62-2
• 分子式：C₁₆H₂₃N₁₁O₂S₅
• 分子量：561.75100
• 发布时间：2018-12-24 10:45:37
• 更新时间：2026-07-31 20:26:28

名称

• 中文名: 法莫替丁相关化合物B
• 英文名: 2-[4-[2-[5-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1,1-dioxo-4H-1,2,4,6-thiatriazin-3-yl]ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine
• 中文别名: 法莫替丁杂质B; 1,1'-(((((1,1-二氧代-2H-1,2,4,6-硫杂三嗪-3,5-二基)双(乙烷-2,1-二基))双(硫烷二基))二(亚甲基)双(噻唑-4,2-二基)二胍; 1,1' - (4,4'-((((1,1-二氧化-4H -1,2,4,6-噻三嗪-3,5-二基)双(乙烷-2,1-二基)) 双(硫烷二基))双(亚甲基))双(噻唑-4,2-二基))二胍 (法莫替丁杂质); 法莫替丁杂质B二马来酸盐; 法莫替丁杂质B D; 法莫替丁相关物质B; 法莫替丁杂质B(提供二马来酸盐C4X-139233); 法莫替丁杂质2(法莫替丁杂质B)
• 英文别名: 3,5-Bis[2-[[[2-[(diaminomethylidene)amino]thiazol-4-yl]methyl]sulfanyl]ethyl]-4H-1,2,4,6-thiatriazine 1,1-dioxide; Guanidine, N,N'''-[(1,1-dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl)bis(2,1-ethanediylthiomethylene-4,2-thiazolediyl)]bis; Famotidine Impurity B; N,N'''-[(1,1-Dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl) bis(2,1-ethanediylthioMethylene-4,2-thiazolediyl)]bisguanidi; 1,1'-(4,4'-((((1,1-Dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl)bis(ethane-2,1-diyl))bis(sulfanediyl))bis(methylene))bis(thiazole-4,2-diyl))diguanidine; Fampridine Impurity 12; Famotidine Impurity 2(Famotidine Impurity B); 1,1'-(4,4'-((((1,1-Dioxido-4H-1,2,4,6-thiatriazine-3,5-diyl)bis(ethane-2,1-diyl))bis(sulfanediyl))bis(methylene))bis(thiazole-4,2-diyl))diguanidine (Famotidine Impurity); UNII-W954S5W09G; 3,5-Bis[2-[[[2-[(diaminomethylidene)amino]thiazol-4-yl]methyl]sulfanyl]ethyl]-4H-1,2,4,6-thiatriazin; Famotidine Impurity B/ Famotidine Related Compound B; Famotidine Related Compound B (3,5-bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]sulphany; FAMOTIDINE RELATED COMPOUND B; 1,1'-(((((1,1-Dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl)bis(ethane-2,1-diyl))bis(sulfanediyl))bis(methylene))bis(thiazole-4,2-diyl))diguanidine; Famotidine Impurity 2; 3,5-Bis[2-[[[2-[(aminoiminomethyl)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-4H-1,2,4,6-thiatriazine-1,1-dioxide; Famotidine Related Compound-B / Famotidine Impurity-B; Famotidine Related Compound B (25 mg) (3,5-bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]sulphany]ethyl]-4H-1,2,4,6-thiatriazine1,1-dioxide) (AS); 3,5-bis[2-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-4H-1,2,4,6-thiatriazine 1,1-dioxide; 2,2'-(((((1,1-dioxido-4H-1,2,4,6-thiatriazine-3,5-diyl)bis(ethane-2,1-diyl))bis(sulfanediyl))bis(methylene))bis(thiazole-4,2-diyl))diguanidine; FaMotidine IMpurity B RC B); Famotidine Impurity B Dimaleate; 3,5-Bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]thio]-ethyl]-4H-1,2,4,6-thiatriazine-1,1-dioxide

物化性质

• 密度: 1.856g/cm3
• 沸点: 782.835ºC at 760 mmHg
• 分子式: C₁₆H₂₃N₁₁O₂S₅
• 分子量: 561.75100
• 闪点: 427.243ºC
• 精确质量: 561.06400
• PSA: 335.93000
• LogP: 3.82900
• 折射率: 1.881

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

76823-94-4 ~37% 89268-62-2

文献：Yanagisawa, Isao; Hirata, Yasufumi; Ishii, Yoshio Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1787 - 1793

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