259809-46-6

• 常用中文名：6-Boc-5,6,7,8-四氢-1,6-萘啶-2-甲腈
• 常用英文名：TERT-BUTYL 2-CYANO-7,8-DIHYDRO-1,6-NAPHTHYRIDINE-6(5H)-CARBOXYLATE
• CAS号：259809-46-6
• 分子式：C₁₄H₁₇N₃O₂
• 分子量：259.304
• 发布时间：2019-01-17 11:19:45
• 更新时间：2025-08-28 10:49:24

名称

• 中文名: 2-氰基-7,8-二氢-1,6-萘啶-6(5H)-羧酸叔丁酯
• 英文名: tert-butyl 2-cyano-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate
• 英文别名: 2-Methyl-2-propanyl 2-cyano-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate; 1,6-Naphthyridine-6(5H)-carboxylic acid, 2-cyano-7,8-dihydro-, 1,1-dimethylethyl ester; 6-boc-2-cyano-5,6,7,8-tetrahydro-1,6-naphthyridine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 401.5±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇N₃O₂
• 分子量: 259.304
• 闪点: 196.6±28.7 °C
• 精确质量: 259.132080
• PSA: 66.22000
• LogP: 1.24
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.564
• 储存条件: 2-8°C

合成路线

79-44-7 259809-45-5 ~58% 259809-46-6

文献：SMITHKLINE BEECHAM CORPORATION Patent: WO2009/56556 A1, 2009 ; Location in patent: Page/Page column 42 ; WO 2009/056556 A1

7677-24-9 259809-45-5 ~87% 259809-46-6

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182

3612-20-2 ~% 259809-46-6

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182

75510-02-0 ~% 259809-46-6

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182

80957-68-2 ~% 259809-46-6

文献：Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182