848139-78-6

• 常用中文名：6-氨基-4-(3-氯-4-(吡啶-2-取代甲氧基)苯胺)-7-乙氧基喹啉-3-甲腈
• 常用英文名：6-amino-4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7-ethoxyquinoline-3-carbonitrile
• CAS号：848139-78-6
• 分子式：C₂₄H₂₀ClN₅O₂
• 分子量：445.901
• 发布时间：2018-12-10 22:02:24
• 更新时间：2026-07-09 18:18:35

名称

• 中文名: 6-氨基-4-(3-氯-4-(吡啶-2-取代甲氧基)苯胺)-7-乙氧基喹啉-3-甲腈
• 英文名: 6-amino-4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7-ethoxyquinoline-3-carbonitrile
• 中文别名: 来那替尼杂质47; 4-[(3-氯-4-(2-吡啶基甲氧基)苯基)氨基]-6-氨基-7-乙氧基喹啉-3-甲腈; 6-氨基-4-[[3-氯-4-(2-甲氧吡啶)苯基]氨基]-7-乙氧基-3-氰基喹啉; 奈拉替尼杂质A; 3-喹啉碳腈,6-氨基-4-[[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基] -7-乙氧基; 6-氨基-4-((3-氯-4-(吡啶-2-基甲氧基)苯基)氨基)-7-乙氧基喹啉-3-氰基; 马来酸奈拉替尼杂质A; 来那替尼中间体6-氨基-4-(3-氯-4-(吡啶-2-取代甲氧基)苯胺)-7-乙氧基喹啉-3-甲腈; 4-[4-[(2-吡啶基)甲氧基]-3-氯苯胺基]-6-氨基-3-氰基-7-乙氧基喹啉; 马来酸奈拉替尼INT2; 6-氨基-4-(3-氯-4-(吡啶-2-基甲氧基)苯氨基)-7-乙氧基喹啉-3-甲腈; 6-氨基-4-((3-氯-4-(吡啶-2-基甲氧基)苯基)氨基)-7-乙氧基喹啉-3-腈
• 英文别名: 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile Free sample Certificate of analysis; 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile TDS msds coa; Des-(4-(dimethylamino)-2-butenoyl)-Neratinib; 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-ethoxy-quinoline-3-carbonitrile hydrochloride; qui129; 6-Amino-4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-3-quinolinecarbonitrile; 6-Amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile; 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-ethoxy-quinoline-3-carbonitrile; 6-amino-4-(3-chloro-4-(pyridin-2-yloxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile; 6-Amino-4-[3-chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxyquinoline; Neratinib Impurity 47; Neratinib Intermediate3; 6-Amino-4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-3-quinolinecbonitrile; 6-Amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxy-3-quinolinecbonitrile; 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-ethoxy-qu; 4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline; T66 BNJ DCN HZ IO2 EMR CG DO1- BT6NJ; 3-Quinolinecbonitrile, 6-amino-4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]amino]-7-ethoxy; 6-Amino-4-((3-chloro-4-(pyridin-2-ylMethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile (Hydrochloride); 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile; 6-Amino-4-[(3-chloro-4-(2-pyridylmethoxy)phenyl)amino]-7-ethoxyquinoline-3-carbonitrile; 6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile; 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile COA Free sample MSDS

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 649.8±55.0 °C at 760 mmHg
• 熔点: 236-238 °C
• 分子式: C₂₄H₂₀ClN₅O₂
• 分子量: 445.901
• 闪点: 346.8±31.5 °C
• 精确质量: 445.130554
• PSA: 109.31000
• LogP: 4.80
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.698
• 储存条件: 2-8°C，避光干燥密封

合成路线