918642-61-2

• 常用中文名：1-((2-氟苯基)氨基甲酰基)环丙烷甲酸(卡博替尼杂质)
• 常用英文名：1-((2-fluorophenyl)carbamoyl)cyclopropanecarboxylicacid(CabozantinibImpurity)
• CAS号：918642-61-2
• 分子式：C₁₁H₁₀FNO₃
• 分子量：223.20000
• 发布时间：2016-06-15 19:26:54
• 更新时间：2024-01-09 09:55:06

名称

• 中文名: 1-((2-氟苯基)氨基甲酰基)环丙烷甲酸(卡博替尼杂质)
• 英文名: 1-[(2-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid
• 英文别名: 1-(2-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid,1-[[(2-fluorophenyl)amino]carbonyl]

物化性质

• 分子式: C₁₁H₁₀FNO₃
• 分子量: 223.20000
• 精确质量: 223.06400
• PSA: 69.89000
• LogP: 2.27850
• 储存条件: 2-8°C

合成路线

348-54-9 ~52% 918642-61-2

文献：Eisai RandD Management Co., Ltd. Patent: EP1889836 A1, 2008 ; Location in patent: Page/Page column 52 ;

40258-99-9 348-54-9 ~% 918642-61-2

文献：Saavedra, Oscar; Claridge, Stephen; Zhan, Lijie; Raeppel, Franck; Granger, Marie-Claude; Raeppel, Stephane; Mannion, Michael; Gaudette, Frederic; Zhou, Nancy; Isakovic, Ljubomir; Bernstein, Naomy; Deziel, Robert; Nguyen, Hannah; Beaulieu, Normand; Beaulieu, Carole; Dupont, Isabelle; Wang, James; Macleod, A. Robert; Besterman, Jeffrey M.; Vaisburg, Arkadii Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6836 - 6839