5130-29-0

• 常用中文名：12-Ketodeoxycholic acid
• 常用英文名：12-Ketodeoxycholic acid
• CAS号：5130-29-0
• 分子式：C₂₄H₃₈O₄
• 分子量：390.55600
• 相关类别： 研究领域 代谢疾病
• 发布时间：2016-09-29 18:14:38
• 更新时间：2026-07-16 11:36:06
• 12-Ketodeoxycholic acid 是一种胆汁酸,是肾脏的代谢物。12-Ketodeoxycholic acid 可以作为肾脏损伤的标志物。

名称

• 中文名: 奥贝胆酸片参比制剂
• 英文名: 12-Ketolithocholic acid
• 中文别名: 12-酮基石胆酸; 12酮石胆酸; 12-Ketodeoxycholic acid #天然产物 HY-135772; 乙腈中12-酮基石胆酸标准溶液; (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-羟基-10,13-二甲基-12-氧代十六氢-1H-环戊烷并[a]菲-17-基)戊酸; 胆酸杂质9; (((3R,5R,8R,9S,10S,13R,14S,17R))-3-羟基-10,13-二甲基-12-氧十六烷-1H-环戊[A]菲蒽-17-基戊酸; 12酮石胆酸,10 MM DMSO 溶液; (R)-4-(((3R,5R,8R,9S,10S,13R,14S,17R))-3-羟基-10,13-二甲基-12-氧十六烷-1H-环戊[A]菲蒽-17-基戊酸
• 英文别名: Cholic Acid Impurity 9; 3-ALPHA-HYDROXY-12-OXO-5-BETA-CHOLANOICACID; (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid; Cholic Acid IMpurity (3-alpha-Hydroxy-12-Oxo-5-beta-Cholanoic Acid); (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; BAA485 (12-Ketodeoxycholic acid); Cholan-24-oic acid, 3-hydroxy-12-oxo-, (3α,5β); Cholic Acid Impurity (3-alpha-Hydroxy-12-Oxo-5-beta-Cholanoic Acid); (4R)-4-((3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 5β-CHOLANIC acid-3α-OL-12-ONE; acid,chronic,12Ketodeoxycholic acid,kidney,12 Ketodeoxycholic acid,Inhibitor,injury,NAFLD,istolochic,nhropathy,inhibit,Endogenous Metabolite,AAN,disease,12-Ketodeoxycholic acid; 12-Ketodeoxycholic acid, 10 mM in DMSO

物化性质

• 分子式: C₂₄H₃₈O₄
• 分子量: 390.55600
• 精确质量: 390.27700
• PSA: 74.60000
• LogP: 4.68610

生物活性

• 描述: 12-Ketodeoxycholic acid 是一种胆汁酸,是肾脏的代谢物。12-Ketodeoxycholic acid 可以作为肾脏损伤的标志物。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点:

  IC50: metabolite from kidney

• 体外研究: 胆汁酸是由胆固醇结合产生的,它被肝脏并入胆汁中,在肠中分泌[1]。
• 参考文献:

  [1]. Chen H, et al. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression.Redox Biol. 2016 Dec;10:168-178.

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