7601-55-0

• 常用中文名：二甲基四碘
• 常用英文名：DIMETHYL TUBOCURARINE IODIDE
• CAS号：7601-55-0
• 分子式：C₄₀H₄₈I₂N₂O₆
• 分子量：906.62800
• 发布时间：2016-09-14 03:46:29
• 更新时间：2024-01-29 18:35:56

名称

• 中文名: 二甲基四碘
• 英文名: Metubine iodide
• 英文别名: metocurine diiodide; Metokuriinijodidi; Metokurinjodid; 6,6',7',12'-Tetramethoxy-2,2,2',2'-tetramethyl-tubocurarandiium,Dijodid; 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-tubocuraranium; 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-tubocurarandiium,diiodide; Dimethyltubocurarine Iodide; Metubine; Methyl-curarin; Mutubine Iodide; O,O'-dimethyl-tubocurarine diiodide; METOCURINE IODIDE

物化性质

• 分子式: C₄₀H₄₈I₂N₂O₆
• 分子量: 906.62800
• 精确质量: 906.16000
• PSA: 55.38000
• LogP: 1.37720

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YO3700000 CHEMICAL NAME : Tubocuraranium, 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-, diiodide CAS REGISTRY NUMBER : 7601-55-0 LAST UPDATED : 199107 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C40-H48-N2-O6.2I MOLECULAR WEIGHT : 906.70 WISWESSER LINE NOTATION : T D6 I6 I-6 R6-18-66 D- D-- I-- R- 2AI- H& CO JK QO B&K&T&&TT&J J1 J1 OO1 SO1 B&1 B&1 G&O1 H& HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 150 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,109,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 370 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,109,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 35 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 ug/kg TOXIC EFFECTS : Behavioral - muscle weakness REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 244,493,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 32 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)

合成路线

74-88-4 ~% 7601-55-0

文献：Journal of the Chemical Society, , p. 1381,1389 Journal of the Chemical Society, , p. 1276,1278 Journal of the American Chemical Society, , vol. 68, p. 419,423 Archiv der Pharmazie (Weinheim, Germany), , vol. 287, p. 555,559

57-94-3 74-88-4 ~% 7601-55-0

文献：Journal of the Chemical Society, , p. 1381,1389 Journal of the Chemical Society, , p. 1276,1278 Journal of the American Chemical Society, , vol. 68, p. 419,423 Archiv der Pharmazie (Weinheim, Germany), , vol. 287, p. 555,559

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