23887-46-9

• 常用中文名：桂哌齐特
• 常用英文名：Cinepazide
• CAS号：23887-46-9
• 分子式：C₂₂H₃₁N₃O₅
• 分子量：417.499
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2018-07-30 16:39:15
• 更新时间：2024-01-04 17:23:54
• Cinepazide是血管扩张剂。

名称

• 中文名: 桂哌齐特
• 英文名: 1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
• 中文别名: 桂哌各特; 1-(吡咯烷-1-基甲酰甲基)-4-(3,4,5-三甲氧基肉桂酰基)哌嗪
• 英文别名: Piperazine,1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl); 1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-4-[3-(3,4,5-trimethoxy-phenyl)-acryloyl]-piperazine; 2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-; 1-((1-Pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine; (2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one; Cinepazida [INN-Spanish]; 1-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]piperazine; 1-[4-[(3',4',5'-Trimethoxycinnamoyl)-1-piperazinyl]acetyl]pyrrolidine; Cinepazidum [INN-Latin]; 1-(PYRROLIDIN-1-YLCARBONYLMETHYL)-4-(3,4,5-TRIMETHOXYCINNAMOYL)PIPERAZINE; Cinepazide; MFCD00868266; 1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine; Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-; Piperazine,1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl); (2E)-1-{4-[2-Oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one; 1-[4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one; Piperazine, 1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)-; EINECS 245-928-9

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 637.8±55.0 °C at 760 mmHg
• 熔点: 170 - 175ºC
• 分子式: C₂₂H₃₁N₃O₅
• 分子量: 417.499
• 闪点: 339.5±31.5 °C
• 精确质量: 417.226379
• PSA: 71.55000
• LogP: 1.64
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.575
• 储存条件: 2-8℃

生物活性

• 描述: Cinepazide是血管扩张剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Akashi, A., et al., [Cardiovascular pharmacology of cinepazide, a new cerebral vasodilator (author's transl)]. Nihon Yakurigaku Zasshi, 1979. 75(5): p. 507-16.

  [2]. Muramatsu, I., et al., Effects of cinepazide on the purinergic responses in the dog cerebral artery. Pharmacology, 1984. 28(1): p. 27-33.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM2486800 CHEMICAL NAME : Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-t rimethoxyphenyl)-2-pr openyl)- CAS REGISTRY NUMBER : 23887-46-9 BEILSTEIN REFERENCE NO. : 0903854 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C22-H31-N3-O5 MOLECULAR WEIGHT : 417.56 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 44640 mg/kg/31D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,375,1979

合成路线

39890-45-4 10263-19-1 ~68% 23887-46-9

文献：Ohtaka; Yoshida; Suzuki; Shimohara; Tajima; Ito Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3948 - 3954

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