133242-30-5

• 常用中文名：兰地洛尔
• 常用英文名：Landiolol
• CAS号：133242-30-5
• 分子式：C₂₅H₃₉N₃O₈
• 分子量：509.592
• 相关类别： 原料药 循环系统用药 β-肾上腺素受体阻断药
• 发布时间：2018-04-25 08:00:00
• 更新时间：2026-07-02 04:00:39

名称

• 中文名: 兰地洛尔
• 英文名: [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate
• 中文别名: 兰地洛尔-[13C4]/精确称量; ((S)-2,2-二甲基-1,3-二氧戊环-4-基)甲基 3-(4-((S)-2-羟基-3-((2-(吗啉-4-甲酰氨基)乙基)氨基)丙氧基)苯基)丙酸酯; [(4S)-2,2-二甲基-1,3-二氧戊环-4-基]甲基 3-[4-[(2S)-2-羟基-3-[2-(吗啉-4-甲酰氨基)乙基氨基]丙氧基]苯基]丙酸酯; 兰地洛尔盐酸盐杂质
• 英文别名: [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-[(2-{[(morpholin-4-yl)carbonyl]amino}ethyl)amino]propoxy]phenyl}propanoate; Landiolol HCL; (S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-hydroxyphenyl)propanoate; [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-({2-[(4-morpholinylcarbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate; [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)propanoate; ONO1101; ((–)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(S)-2-hydroxy-3-(2-morpholino-cbonylamino)ethylamino] propoxy}phenylpropionate); Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester; [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-cbonylamino)ethylamino]propoxy]phenyl]propanoate; (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-hydroxy-3-(2-morpholino-cbonylamino)ethylamino]propoxy]phenylpropionate monohydrochloride; Landiolol D8; ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholine-4-carboxamido)ethylamino)propoxy)phenyl)propanoate; benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester; ((4S)-2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-(((2S)-2-Hydroxy-3-((2-((morpholin-4-ylcarbonyl)amino)ethyl)amino)propyl)oxy)phenyl)propanoate; 2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-(4-hydroxyphenyl)propionate; Landiolol //BP; ONO-1101; 2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-(4-{3-[2-(morpholinocarbonylamino)ethylamino]-2S-hydroxypropoxy}phenyl)propionate; ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-cboxamido)ethyl)amino)propoxy)phenyl)propanoate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 727.5±60.0 °C at 760 mmHg
• 熔点: 125.4ºC
• 分子式: C₂₅H₃₉N₃O₈
• 分子量: 509.592
• 闪点: 393.8±32.9 °C
• 精确质量: 509.273712
• PSA: 127.82000
• LogP: 0.80
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.531

合成路线

1398109-46-0 154467-16-0 ~72% 133242-30-5

文献：EP2687521 A1, ; Paragraph 0045; 0046; 0047; 0048; 0049; 0050 ;

69630-16-6 144256-12-2 ~65% 133242-30-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469

144256-11-1 ~% 133242-30-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469

501-97-3 ~% 133242-30-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469

23735-43-5 ~% 133242-30-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469

93605-74-4 ~% 133242-30-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 6 p. 1462 - 1469

上下游产品

上游产品  5
154467-16-0 69630-16-6 144256-11-1 501-97-3
23735-43-5
下游产品  1
144481-98-1