199850-67-4

• 常用中文名：N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸
• 常用英文名：PD 166793
• CAS号：199850-67-4
• 分子式：C₁₇H₁₈BrNO₄S
• 分子量：412.29800
• 相关类别： 生物化工 氨基酸及其衍生物 缬氨酸类衍生物
• 发布时间：2019-01-02 22:02:03
• 更新时间：2024-01-09 10:29:55
• PD-166793 is a cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

名称

• 中文名: (S)-2-(4’-溴联苯-4-磺酰胺)-3-甲基丁酸
• 英文名: (2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
• 中文别名: N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸

物化性质

• 密度: 1.457g/cm3
• 沸点: 562.069ºC at 760 mmHg
• 熔点: 192-193℃
• 分子式: C₁₇H₁₈BrNO₄S
• 分子量: 412.29800
• 闪点: 293.729ºC
• 精确质量: 411.01400
• PSA: 91.85000
• LogP: 4.97530
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.597
• 储存条件: Desiccate at +4°C

合成路线

199850-87-8 ~68% 199850-67-4

文献：O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

92-66-0 ~% 199850-67-4

文献：O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

13610-11-2 ~% 199850-67-4

文献：O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

78079-08-0 ~% 199850-67-4

文献：O'Brien, Patrick M.; Ortwine, Daniel F.; Pavlovsky, Alexander G.; Picard, Joseph A.; Sliskovic, Drago R.; Roth, Bruce D.; Dyer, Richard D.; Johnson, Linda L.; Man, Chiu Fai; Hallak, Hussein Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 156 - 166

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