425-51-4

• 常用中文名：醋酸氯地酮杂质K
• 常用英文名：[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
• CAS号：425-51-4
• 分子式：C₂₃H₃₀O₄
• 分子量：370.48200
• 发布时间：2017-07-31 19:34:22
• 更新时间：2025-09-08 15:11:27

名称

• 中文名: 醋酸氯地酮杂质K
• 英文名: [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
• 中文别名: 醋酸氯地黄酮 杂质 K; 醋酸氯马定杂质K; 孕酮杂质4; 醋酸氯地孕酮杂质K; (8R,9S,10R,13S,14S,17R)-17-乙酰基-10,13-二甲基-3-氧代-2,3,8,9,10,11,12,13,14,15,16,17-十二氢-1H-环戊基[A]菲-17-乙酸酯 (醋酸氯马地酮杂质)
• 英文别名: 6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione; 3,20-dioxopregna-4,6-dien-17-yl acetate; Megestil; 6,7-Dehydro-17α-acetoxy Progesterone; Melengestro acetate; Pregna-4,6-diene-3,20-dione, 17-(acetyloxy); "6,7-Dehydro-17α-acetoxy Progesterone D6"; Δ6-Acetoxyprogesterone; 6,7-Dehydro-17alpha-acetoxy Progesterone; 17-Hydroxypregna-4,6-diene-3,20-dione acetate; 17-(Acetyloxy)pregna-4,6-diene-3,20-dione; 6,7-Dehydro-17Alpha-acetoxy Progesterone; Chlormadinone Acetate Impurity K; (8R,9S,10R,13S,14S,17R)-17-Acetyl-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Chlormadinone Acetate Impurity); 17-acetoxy-pregna-4,6-diene-3,20-dione; Progesterone Impurity 4

物化性质

• 密度: 1.16g/cm3
• 沸点: 504.7ºC at 760mmHg
• 分子式: C₂₃H₃₀O₄
• 分子量: 370.48200
• 闪点: 218.7ºC
• 精确质量: 370.21400
• PSA: 60.44000
• LogP: 4.18520

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4067000 CHEMICAL NAME : Pregna-4,6-diene-3,20-dione, 17-hydroxy-, acetate (ester) CAS REGISTRY NUMBER : 425-51-4 LAST UPDATED : 198910 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C23-H30-O4 MOLECULAR WEIGHT : 370.53 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 25 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility REFERENCE : ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 25 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility REFERENCE : ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,3,1963 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

合成路线

4134-58-1 ~99% 425-51-4

文献：Boehringer Ingelheim International GmbH Patent: EP1359154 A1, 2003 ; Location in patent: Page/Page column title page; 4; 17; 25; 30; 32 ;

1054-64-4 ~% 425-51-4

文献：Yasuda,K. Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 1167 - 1174

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