76129-12-9

• 常用中文名：Acetamide, N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-9-oxo-10-[(phenylmethyl)thio]benzo[c]heptalen-7-yl]-, (S)-
• 常用英文名：Acetamide, N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-9-oxo-10-[(phenylmethyl)thio]benzo[c]heptalen-7-yl]-, (S)-
• CAS号：76129-12-9
• 分子式：C₂₈H₂₉NO₅S
• 分子量：491.59900
• 发布时间：2016-02-21 21:20:06
• 更新时间：2025-09-21 07:29:34

名称

• 英文名: Acetamide, N-[5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-[(phenylmethyl)thio]benzo[c]heptalen-7-yl]-, (S)
• 英文别名: N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-10-(benzylthio)benzo[a]heptalen-7-yl]acetamide; N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-benzylthio-9-oxobenzo[a]heptalen-7-yl]acetamide; 10-(Benzylthio)-10-demethoxycolchicine; (S)-7-Acetylamino-10-benzylmercapto-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-((S)-10-Benzylmercapto-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid; 10-benzylthiocolchicine; N-((S)-10-benzylsulfanyl-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

物化性质

• 密度: 1.27g/cm3
• 沸点: 787.6ºC at 760 mmHg
• 分子式: C₂₈H₂₉NO₅S
• 分子量: 491.59900
• 闪点: 430.1ºC
• 精确质量: 491.17700
• PSA: 99.16000
• LogP: 5.54620
• 折射率: 1.634

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC8756000 CHEMICAL NAME : Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-((phe nylmethyl)thio)benzo( a) heptalen-7-yl)-, (S)- CAS REGISTRY NUMBER : 76129-12-9 BEILSTEIN REFERENCE NO. : 3185560 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C28-H29-N-O5-S MOLECULAR WEIGHT : 491.64 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 ES1R& JMV1 NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

合成路线

64-86-8 100-53-8 ~% 76129-12-9

文献：Velluz; Muller Bulletin de la Societe Chimique de France, 1954 , p. 194,195

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