54193-28-1

• 常用中文名：阿霉素醇
• 常用英文名：Doxorubicinol
• CAS号：54193-28-1
• 分子式：C₂₇H₃₁NO₁₁
• 分子量：545.54
• 发布时间：2016-02-17 16:08:42
• 更新时间：2026-07-23 17:39:50
• 阿霉素是心肌肌浆网钙泵的有效抑制剂,可抑制离体心肌的收缩心肌功能。阿霉素抑制肿瘤细胞生长并具有心脏毒性。

名称

• 中文名: 阿霉素醇
• 英文名: adriamycinol
• 中文别名: 2H3]-阿霉素醇三氟乙酸盐; 氘3-多柔比星醇三氟乙酸盐; 13C,2H3]-阿霉素甲酸盐; 多柔比星醇三氟乙酸盐/精确称量; 多柔比星醇; 多柔比星相关杂质; 13C,2H3]-阿霉素三氟乙酸盐; 表柔比星(表阿霉素)杂质22
• 英文别名: 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S); 14-hydroxydaunomycinone; Doxorubicinol acetate salt; DoxorubicinolQ: What is Doxorubicinol Q: What is the CAS Number of Doxorubicinol Q: What is the storage condition of Doxorubicinol Q: What e the applications of Doxorubicinol; 2H3]-Doxorubicinol trifluoroacetate salt; doxorubicin aglycone; 13C,2H3]-Doxorubicinol formate salt; D3-Doxorubicinol trifluoroacetate salt; ADRIAMYCINOL; Doxorubicinol TFA SaltQ: What is Doxorubicinol TFA Salt Q: What is the CAS Number of Doxorubicinol TFA Salt Q: What is the storage condition of Doxorubicinol TFA Salt; antibiotic27706rp; (8S)-7,8,9,10-Tetrahydro-10α-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(S)-1,2-dihydroxyethyl]-1-methoxy-6,8α,11-trihydroxy-5,12-naphthacenedione; Doxorubicinol CitrateQ: What is Doxorubicinol Citrate Q: What is the CAS Number of Doxorubicinol Citrate Q: What is the storage condition of Doxorubicinol Citrate; Epirubicin aglycon; Doxorubicinol-13C D3 citrate; 13-dihydrodoxorubicin; 13-dihydroxorubicin; Doxorubicinol,mixture of diastereomers; adriamycinaglycone; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-(1,2-dihydroxyethyl)-1-methoxy-6,8,11-trihydroxy-, (8S-(8-alpha,8(R*),10-alpha)); 8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione; Adriamycin-aglycon; DOXORUBICINOL; Doxorubicinol (See also D558020); (1S,3S)-3-[(1S)-1,2-Dihydroxyethyl]-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; 2-dihdyroxyethyl)-1-methoxy-6,8,11-trihydroxy-lyxo-hexopyranosyl)oxy)-8-((; Epirubicin aglycone; doxorubicin hydroxyaglycone; 8(r*),10-alpha))-8s-(8-alph; 5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-8-(1S)-1,2-dihydroxyethyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S); Doxorubicinone; RP-27706

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 828.7±65.0 °C at 760 mmHg
• 分子式: C₂₇H₃₁NO₁₁
• 分子量: 545.54
• 闪点: 455.0±34.3 °C
• 精确质量: 545.189697
• PSA: 209.23000
• LogP: 2.01
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.717

生物活性

• 描述: 阿霉素是心肌肌浆网钙泵的有效抑制剂,可抑制离体心肌的收缩心肌功能。阿霉素抑制肿瘤细胞生长并具有心脏毒性。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 阿霉素抑制分离的乳头肌的舒张功能(即增加静息压)[1] 阿霉素在显著降低舒张功能的浓度下,阿霉素几乎完全消除钙泵活性[1] 阿霉素抑制 钙离子刺激的骨骼肌肌浆网的 三磷酸腺苷酶活性,并消除犬和兔心脏制备物中肌膜的 Na+/K+-ATP酶活性[1] 阿霉素抑制 潘克-1细胞的增殖,IC50值为 35.4μM,帕金森氏症PaCa细胞的 IC50值为 44.5μM,WD帕钙细胞的 IC50值为 49.5微米[1]
• 参考文献:

  [1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9326000 CHEMICAL NAME : 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha -L-lyxo- hexopyranosyl)oxy)-8-(1,2-dihdyroxyethyl)-1-methoxy-6 ,8,11-trihydroxy-, (8S-(8-alpha,8(R*), 10-alpha))- CAS REGISTRY NUMBER : 54193-28-1 LAST UPDATED : 199706 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C27-H31-N-O11 MOLECULAR WEIGHT : 545.59 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 26900 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1006,1981

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