116-58-5

• 常用中文名：20β-二氢皮质醇
• 常用英文名：20-BETA-DIHYDROCORTISOL
• CAS号：116-58-5
• 分子式：C₂₁H₃₂O₅
• 分子量：364.47600
• 发布时间：2016-09-07 06:10:08
• 更新时间：2026-08-02 15:27:25

名称

• 中文名: 20β-二氢皮质醇
• 英文名: (8S,9S,10R,11S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• 中文别名: 20Β-羟基可的松; 氢化可的松杂质
• 英文别名: 20beta-Dihydrocortisol; 11B,17ALPHA,20B,21-Tetrahydroxy-4-pregnen-3-one; Reichstein's substance E; 4-PREGNEN-11β, 17, 20β, 21-TETROL-3-ONE; UNII-77U6C4OLOR; 20beta-hydroxycortisol; 20b-Dihydrocortisol; delta4-Pregnene-11beta,17alpha,20beta,21-tetraol-3-one; Hydrocortisone Impurity; 4-Pregnene-11beta,17alpha,20beta,21-tetrol-3-one; 11β,17α,20β,21-Tetrahydroxy-4-pregnen-3-one; 202-Dihydrocortisol; REICHSTEIN'S SUBSTANCE 'E'; 4-pregnene-11B,17A,20B,21-tetrol-3-one; 4-pregnene-11beta,17alpha,20beta,21-tetrol-3-one; 4-PREGNEN-11BETA,17ALPHA,20BETA,21-TETROL-3-ONE; REICHSTEIN'S COMPOUND ''E''; 4-Pregnene-11β,17α,20β,21-tetrol-3-one; 11-beta,17-alpha-20-beta,21-tetrahydroxypregn-4-en-3-one; Reichstein's compound E; 20β-Dihydrocortisol; 4-PREGNEN-11-BETA, 17,20-BETA, 21-TETROL-3-ONE; Pregn-4-en-3-one, 11,17,20,21-tetrahydroxy-, (11β,20R); Reichstein’S Substance ‘E’; 20beta-Hydroxycortisol

物化性质

• 密度: 1.29g/cm3
• 沸点: 586.6ºC at 760 mmHg
• 分子式: C₂₁H₃₂O₅
• 分子量: 364.47600
• 闪点: 322.6ºC
• 精确质量: 364.22500
• PSA: 97.99000
• LogP: 1.57340
• 蒸汽压: 3.34E-16mmHg at 25°C
• 折射率: 1.602
• 分子结构:

  1、 摩尔折射率：96.96

  2、 摩尔体积（cm³/mol）：282.4

  3、 等张比容（90.2K）：789.0

  4、 表面张力（dyne/cm）：60.9

  5、 极化率（10-24cm3）：38.44

合成路线

1852-65-9 ~% 116-58-5

文献：Sarett et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 1777

123267-88-9 ~% 116-58-5

文献：Huang-Minlon; Pettebone Journal of the American Chemical Society, 1952 , vol. 74, p. 1562

50-23-7 ~0% 1719-79-5 116-58-5

文献：Han; Monder Steroids, 1983 , vol. 42, # 6 p. 619 - 626

50-23-7 ~% 116-58-5

文献：Carvajal et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 695,697 Full Text Show Details Lindner et al. Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1958 , vol. 313, p. 117,122 Full Text Show Details Kogan et al. Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1963 , p. 328,330;engl.Ausg.S.298

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