毒理学数据:
1.急性毒性
LD50：210mg/kg（大鼠经口）
LC50：33mg/m3（小鼠吸入，7h）
2.刺激性 暂无资料
3.致突变性
微生物致突变：鼠伤寒沙门菌20μg/皿。程序外DNA合成：小鼠皮肤染毒部位360μmol/kg。
4.致癌性 IARC致癌性评论：G1，确认人类致癌物。
生态学数据:
1.生态毒性 LC50：0.9~3.4mg/L（96h）（鱼）
2.生物降解性
好氧生物降解（h）：168~672
厌氧生物降解（h）：672~2688
3.非生物降解性
空气中光氧化半衰期（h）：0.196~1.96
一级水解半衰期（h）：0.106
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KN1575000
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CHEMICAL NAME :
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Ether, bis(chloromethyl)
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CAS REGISTRY NUMBER :
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542-88-1
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BEILSTEIN REFERENCE NO. :
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1679223
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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56
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MOLECULAR FORMULA :
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C2-H4-Cl2-O
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MOLECULAR WEIGHT :
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114.96
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WISWESSER LINE NOTATION :
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G1O1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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3 ppm
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
-
LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
-
Human - man
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DOSE/DURATION :
-
100 ppm/3M
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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210 uL/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
-
7 ppm/7H
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TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage
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TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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25 mg/m3/6H
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - rabbit
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DOSE/DURATION :
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280 uL/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - hamster
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DOSE/DURATION :
-
7 ppm/7H
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TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
100 ppb/6H/4W-I
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TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
375 mg/kg/43W-I
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TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
100 ppb/6H/26W-I
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
5520 mg/kg/23W-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
50 mg/kg/61W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
384 mg/kg/42W-I
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
640 mg/kg/53W-I
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
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TYPE OF TEST :
-
TC - Toxic concentration (other than lowest)
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
100 ppb/6H/6W-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
12500 ug/kg
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - hair
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TYPE OF TEST :
-
TC - Toxic concentration (other than lowest)
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
100 ppb/6H/26W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TC - Toxic concentration (other than lowest)
-
ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
1 ppm/82D-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains
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TYPE OF TEST :
-
TC - Toxic concentration (other than lowest)
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
75 ppb/6H/2Y-I
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TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
11 gm/kg/44W-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
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TYPE OF TEST :
-
Unscheduled DNA synthesis
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TYPE OF TEST :
-
DNA inhibition
MUTATION DATA
-
TYPE OF TEST :
-
Morphological transformation
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TEST SYSTEM :
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Rodent - hamster Kidney
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REFERENCE :
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BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,873,1978 *** REVIEWS *** ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.0047 mg/m3 (0.001 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,131,1987 TOXICOLOGY REVIEW ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC. Volume(issue)/page/year: 166,113,1978 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Construc):see CFR 29,1926.1108 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1008,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.001 ppm (0.0047 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 0.001 ppm (0.004 mg/m3);STEL 0.003 ppm;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-INDIA:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.001 ppm JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.001 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BIS(CHLOROMETHYL) ETHER-air:CA use 29 CFR 1910.1008 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6315 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated) No. of Female Employees: 5 (estimated)
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