27523-40-6

• 常用中文名：异康唑
• 常用英文名：Isoconazole
• CAS号：27523-40-6
• 分子式：C₁₈H₁₄Cl₄N₂O
• 分子量：416.129
• 相关类别： 原料药 人工合成抗感染类药 抗真菌类药
• 发布时间：2018-07-21 14:56:13
• 更新时间：2025-08-30 10:34:47

名称

• 中文名: 异康唑
• 英文名: 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
• 中文别名: 邻氯益康唑
• 英文别名: Travogyn; Isoconazol; 1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole; Travogen; 1-{2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole; fazol; Isoconazole; 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-; 1-[2,4-Dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]imidazole; Isoconazolum

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 555.1±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₄Cl₄N₂O
• 分子量: 416.129
• 闪点: 289.5±30.1 °C
• 精确质量: 413.986023
• PSA: 27.05000
• LogP: 5.93
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 2-8°C
• 水溶解性: Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI4775700 CHEMICAL NAME : 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)meth oxy)ethyl)- CAS REGISTRY NUMBER : 27523-40-6 LAST UPDATED : 199303 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C18-H14-Cl4-N2-O MOLECULAR WEIGHT : 416.14 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 189 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 13,195,1990

合成路线

2631-72-3 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

4252-78-2 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

46503-52-0 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

13692-14-3 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

53066-15-2 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

24155-42-8 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

2014-83-7 ~% 27523-40-6

文献：Dulcevscaia, Galina M.; Kravtsov, Victor Ch.; Macaev, Fliur Z.; Duca, Gheorghe G.; Stingachi, Eugenia P.; Pogrebnoi, Serghei I.; Boldescu, Veaceslav V.; Clapco, Steliana F.; Tiurina, Janeta P.; Deseatnic-Ciloci, Alexandra A.; Lipkowski, Janusz; Liu, Shi-Xia; Decurtins, Silvio; Baca, Svetlana G. Polyhedron, 2013 , vol. 52, p. 106 - 114

上下游产品

上游产品  6
2631-72-3 4252-78-2 46503-52-0 13692-14-3
24155-42-8 2014-83-7
下游产品  0