CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CL5629500
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CHEMICAL NAME :
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2-Azabicyclo(2.2.2)octane, 2-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylprop yl)-
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CAS REGISTRY NUMBER :
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57726-65-5
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C25-H29-N3-O
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MOLECULAR WEIGHT :
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387.57
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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105 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1,1,1981
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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21 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Behavioral - analgesia Gastrointestinal - decreased motility or constipation
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 210,327,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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399 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
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REFERENCE :
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NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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95 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
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REFERENCE :
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NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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258 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
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REFERENCE :
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NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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12 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
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REFERENCE :
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NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937- Volume(issue)/page/year: 38,1621,1979
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