135729-78-1

• 常用中文名：N-(3S)-1-氮杂双环[2.2.2] oct-3-yl-5,6,7,8-四氢-1-萘甲酰胺
• 常用英文名：(S)-N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDE
• CAS号：135729-78-1
• 分子式：C₁₈H₂₄N₂O
• 分子量：284.396
• 发布时间：2018-12-25 13:07:32
• 更新时间：2026-07-29 17:37:47

名称

• 中文名: (S)-N-(1-氮杂双环环[2.2.2]-3-辛基)-5,6,7,8-四氢-1-萘羧酰胺
• 英文名: N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide
• 中文别名: (S)-N-(1-氮杂双环[2.2.2]辛-3-基)-5,6,7,8-四氢-1-萘甲酰胺; 帕洛诺司琼杂质20; 帕洛诺司琼杂质41; 帕洛诺司琼中间体 3; 帕洛诺司琼杂质帕洛诺司琼杂质20; 帕洛诺司琼杂质3; 盐酸帕洛诺司琼中间体; (S)-N-(奎宁环素-3-基)-5,6,7,8-四氢萘-1-甲酰胺; 帕洛诺司琼杂质27; 帕洛诺司琼杂质25
• 英文别名: N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-cboxamide; Palonosetron Impurity 3; (S)-N-(Quinuclidin-3-yl)-5,6,7,8-tetrahydronaphthalene-1-cboxaMide; Palonosetron Impurity 20; Palonosetron Impurity 1; 5,6,7,8-Tetrahydro-naphthalene-1-ca; rboxylic acid (1-aza-bicyclo[2.2.2]; oct-3-yl)-amide; N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxamide; (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecboxamide; (S)-N-1-azabicyclo[2.2.0]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecboxamide; N-((S)-1-azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide; 1-Naphthalenecboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro; N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl] 5,6,7,8-tetrahydronaphthalene-1-cboxamide; N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide; Palonosetron Intermediate; (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetra; 1-Naphthalenecarboxamide,N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro; Palonosetron Impurity 25; N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecboxaMide; Palonosetron Impurity 27; N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxide; N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 439.2±45.0 °C at 760 mmHg
• 分子式: C₁₈H₂₄N₂O
• 分子量: 284.396
• 闪点: 219.4±28.7 °C
• 精确质量: 284.188873
• PSA: 32.34000
• LogP: 3.41
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.610

安全

• 海关编码: 2933990090

合成路线

4242-18-6 ~% 135729-78-1

文献：Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2645 - 2657

110808-69-0 6530-09-2 ~96% 135729-78-1

文献：Rossetto, Pierluigi; MacDonald, Peter; Bigatti, Ettore; Banfi, Gaia; Tentorio, Dario Patent: US2008/200681 A1, 2008 ; Location in patent: Page/Page column 11 ;

110808-69-0 120570-05-0 ~91% 135729-78-1

文献：DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; SAGYAM, Rajeshwar Reddy; SUNKARA, Vishnuvardhan; MUNAGALA, Sridhar; MUTTAVARAPU, Murali Mohan Patent: WO2010/56656 A2, 2010 ; Location in patent: Page/Page column 22 ;

79-37-8 4242-18-6 120570-05-0 ~% 135729-78-1

文献：US5202333 A1, ;

上下游产品

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%