218451-34-4

• 常用中文名：4-(4-氯苯基)-4-氰基哌啶-1-羧酸叔丁酯
• 常用英文名：tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate
• CAS号：218451-34-4
• 分子式：C₁₇H₂₁ClN₂O₂
• 分子量：320.814
• 发布时间：2019-07-06 16:34:16
• 更新时间：2024-04-03 17:11:55

名称

• 中文名: 4-(4-氯苯基)-4-氰基-1-哌啶羧酸叔丁酯
• 英文名: tert-butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate
• 英文别名: MFCD11227117

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 447.9±45.0 °C at 760 mmHg
• 分子式: C₁₇H₂₁ClN₂O₂
• 分子量: 320.814
• 闪点: 224.7±28.7 °C
• 精确质量: 320.129150
• PSA: 53.33000
• LogP: 3.28
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.559
• 储存条件: 2-8°C，干燥密封

安全

• 海关编码: 2933399090

合成路线

118753-70-1 140-53-4 ~67% 218451-34-4

文献：Caldwell, John J.; Davies, Thomas G.; Donald, Alastair; McHardy, Tatiana; Rowlands, Martin G.; Aherne, G. Wynne; Hunter, Lisa K.; Taylor, Kevin; Ruddle, Ruth; Raynaud, Florence I.; Verdonk, Marcel; Workman, Paul; Garrett, Michelle D.; Collins, Ian Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2147 - 2157

623-03-0 118753-70-1 ~41% 218451-34-4

文献：ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane Patent: WO2013/10453 A1, 2013 ; Location in patent: Page/Page column 126 ;

118753-70-1 ~% 218451-34-4

文献：ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED Patent: WO2006/51290 A2, 2006 ; Location in patent: Page/Page column 120-121; 133 ; WO 2006/051290 A2

24424-99-5 ~% 218451-34-4

文献：ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane Patent: WO2013/10453 A1, 2013 ;

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%