80357-45-5

• 常用中文名：5-bromo-2,6-dimethyl-4-oxo-N,1-diphenylpyridine-3-carboxamide
• 常用英文名：5-bromo-2,6-dimethyl-4-oxo-N,1-diphenylpyridine-3-carboxamide
• CAS号：80357-45-5
• 分子式：C₂₀H₁₇BrN₂O₂
• 分子量：397.26500
• 发布时间：2016-10-08 11:33:34
• 更新时间：2024-09-02 05:04:27

名称

• 英文名: 5-bromo-2,6-dimethyl-4-oxo-N,1-diphenylpyridine-3-carboxamide
• 英文别名: 1,4-Dihydro-5-bromo-2,6-dimethyl-N,1-diphenyl-4-oxonicotinamide; 5-bromo-1,4-dihydro-2,6-dimethyl-N,1-diphenyl-4-oxo-3-pyridinecarboxamide; Nicotinamide,1,4-dihydro-5-bromo-2,6-dimethyl-N,1-diphenyl-4-oxo; 1,4-Dihydro-5-bromo-2,6-dimethyl-N,1-diphenyl-4-oxo-3-pyridinecarboxamide

物化性质

• 密度: 1.473g/cm3
• 沸点: 535ºC at 760 mmHg
• 分子式: C₂₀H₁₇BrN₂O₂
• 分子量: 397.26500
• 闪点: 277.4ºC
• 精确质量: 396.04700
• PSA: 54.59000
• LogP: 4.85310
• 折射率: 1.675

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QS4470500 CHEMICAL NAME : Nicotinamide, 1,4-dihydro-5-bromo-2,6-dimethyl-N,1-diphenyl-4-oxo- CAS REGISTRY NUMBER : 80357-45-5 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H17-Br-N2-O2 MOLECULAR WEIGHT : 397.30 WISWESSER LINE NOTATION : T6N DVJ AR& B1 CVMR& EE F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 562 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,131,1982

合成路线

65190-89-8 ~82% 80357-45-5

文献：Pierce, James Benjamin; Ariyan, Zaven S.; Ovenden, Gaye Stuart Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 131 - 136

24572-69-8 ~% 80357-45-5

文献：Pierce, James Benjamin; Ariyan, Zaven S.; Ovenden, Gaye Stuart Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 131 - 136