1251164-95-0

• 常用中文名：[4-[[(1,1-二甲基乙基)氧基]羰基]-2,3,4,5-四氢-1,4-苯并氮杂卓-7-基]硼酸
• 常用英文名：(4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1,4-be nzoxazepin-7-yl)boronic acid
• CAS号：1251164-95-0
• 分子式：C₁₄H₂₀BNO₅
• 分子量：293.12300
• 发布时间：2018-12-04 10:45:35
• 更新时间：2023-01-16 16:03:00

名称

• 中文名: [4-[[(1,1-二甲基乙基)氧基]羰基]-2,3,4,5-四氢-1,4-苯并氮杂卓-7-基]硼酸
• 英文名: (4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1,4-be nzoxazepin-7-yl)boronic acid
• 英文别名: <4.4.2>Propella-3,11-dien

物化性质

• 分子式: C₁₄H₂₀BNO₅
• 分子量: 293.12300
• 精确质量: 293.14300
• PSA: 79.23000
• LogP: 0.43380

合成路线

24424-99-5 ~% 1251164-95-0

文献：EXELIXIS, INC.; KENNETH, Rice Patent: WO2012/74869 A1, 2012 ; WO 2012/074869 A1

21974-51-6 ~% 1251164-95-0

文献：Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; Anand, Neel K.; Arcalas, Arlyn; Baik, Tae Gon; Buhr, Chris A.; Cannoy, Jonah; Epshteyn, Sergey; Joshi, Anagha; Lara, Katherine; Lee, Matthew S.; Wang, Longcheng; Leahy, James W.; Nuss, John M.; Aay, Naing; Aoyama, Ron; Foster, Paul; Lee, Jae; Lehoux, Isabelle; Munagala, Narsimha; Plonowski, Arthur; Rajan, Sharmila; Woolfrey, John; Yamaguchi, Kyoko; Lamb, Peter; Miller, Nicole Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2218 - 2234