1830-32-6

• 常用中文名：阿嗪米特
• 常用英文名：azintamide
• CAS号：1830-32-6
• 分子式：C₁₀H₁₄ClN₃OS
• 分子量：259.76
• 相关类别： 原料药 消化系统用药 利胆药
• 发布时间：2018-07-03 17:42:18
• 更新时间：2024-01-03 04:27:12
• 阿嗪他胺(Bilipurum)可用于寻常型银屑病、消化不良等病症的研究[1][2]。

名称

• 中文名: 阿嗪米特
• 英文名: 2-(6-chloropyridazin-3-yl)sulfanyl-N,N-diethylacetamide
• 英文别名: Oragallin; Azinthiamide; Oragal; Oragalin; Oragallin purum; Biloral; Azintamid; Bilipurum; Colerin; Azintamide

物化性质

• 密度: 1.27g/cm3
• 沸点: 435.3ºC at 760 mmHg
• 熔点: 97ºC
• 分子式: C₁₀H₁₄ClN₃OS
• 分子量: 259.76
• 闪点: 217ºC
• 精确质量: 259.05500
• PSA: 71.39000
• LogP: 2.09050
• 蒸汽压: 8.88E-08mmHg at 25°C
• 折射率: 1.573
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.9

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积:71.4

  7.重原子数量:16

  8.表面电荷:0

  9.复杂度:226

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: 阿嗪他胺(Bilipurum)可用于寻常型银屑病、消化不良等病症的研究[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zhu L, et, al. [Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial]. Zhonghua Nei Ke Za Zhi. 2008 Nov;47(11):910-3.

  [2]. Diezel W, et, al. [Azintamid as a therapeutic agent in psoriasis vulgaris - a therapeutic study]. Dermatol Monatsschr. 1983;169(8):521-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AB5836500 CHEMICAL NAME : Acetamide, 2-((6-chloro-3-pyridazinyl)thio)-N,N-diethyl- CAS REGISTRY NUMBER : 1830-32-6 BEILSTEIN REFERENCE NO. : 0885011 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H14-Cl-N3-O-S MOLECULAR WEIGHT : 259.78 WISWESSER LINE NOTATION : T6NNJ CG FS1VN2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,266,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1150 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974