39204-47-2

• 常用中文名：2-氯甲基吡嗪
• 常用英文名：2-(Chloromethyl)pyrazine
• CAS号：39204-47-2
• 分子式：C₅H₅ClN₂
• 分子量：128.560
• 相关类别： 医药中间体 杂环化合物 吡嗪类化合物
• 发布时间：2018-03-11 08:00:00
• 更新时间：2024-01-10 04:42:31

名称

• 中文名: 2-氯甲基吡嗪
• 英文名: 2-(Chloromethyl)pyrazine
• 中文别名: 2-[叔丁氧羰基]氨基]-3-丁炔酸甲酯
• 英文别名: 2-(Chloromethyl)pyrazine; Pyrazine, (chloromethyl)-; Pyrazine, 2-(chloromethyl)-; 3-Butynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,methylester(9CI)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 202.9±25.0 °C at 760 mmHg
• 分子式: C₅H₅ClN₂
• 分子量: 128.560
• 闪点: 95.3±8.8 °C
• 精确质量: 128.014130
• PSA: 25.78000
• LogP: -0.01
• 外观性状: 黄色至棕色液体
• 蒸汽压: 0.4±0.4 mmHg at 25°C
• 折射率: 1.534
• 储存条件: 室温， 密封， 干燥

合成路线

109-08-0 ~86% 39204-47-2

文献：Newkome, George R.; Kiefer, Garry E.; Yuan-Jiao Xia; Gupta, Vinod K. Synthesis, 1984 , # 8 p. 676 - 679

6705-33-5 ~21% 39204-47-2

文献：ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory Patent: WO2013/142269 A1, 2013 ; Location in patent: Paragraph 0539; 0540 ;

109-08-0 ~15% 40639-68-7 39204-47-2

文献：Rubina, K. I.; Iovel', I. G.; Gol'dberg, Yu. Sh.; Shimanskaya, F. V. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 4 p. 454 - 457 Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 4 p. 543 - 546

109-08-0 128-09-6 ~% 39204-47-2

文献：Merck Sharp and Dohme Limited Patent: US5444074 A1, 1995 ; US 5444074 A

98-97-5 ~% 39204-47-2

文献：ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory Patent: WO2013/142269 A1, 2013 ;

6164-79-0 ~% 39204-47-2

文献：ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory Patent: WO2013/142269 A1, 2013 ;