| 中文名 |
阿卡明
|
| 英文名 |
Orazamide
|
| 中文别名 |
奥拉米特
5-氨基咪唑-4-甲酰胺乳清酸盐
|
| 英文别名 |
5-Aminoimidazole-4-carboxamide orotate
4-amino-5-imidazolecarboxamideorotatedihydrate
orazamidedihydrate
aicaorotatedihydrate
5-aminoimidazole-4-carboxamideorotatedihydrate
5-Aminoimedazole-4-carboxamideorotate
EINECS 219-923-7
MFCD00867162
AICA orotate
aicamindihydrate
aicoratdihydrate
|
| 沸点 |
700.6ºC at 760mmHg |
| 分子式 |
C9H14N6O7 |
| 分子量 |
318.24300 |
| 闪点 |
377.5ºC |
| 精确质量 |
318.09200 |
| PSA |
219.27000 |
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
NI3915000
-
CAS REGISTRY NUMBER :
-
2574-78-9
-
LAST UPDATED :
-
199009
-
DATA ITEMS CITED :
-
2
-
MOLECULAR FORMULA :
-
C9-H10-N6-O5.2H2-O
-
MOLECULAR WEIGHT :
-
318.29
-
WISWESSER LINE NOTATION :
-
T6MVMVJ FVQ &T5M CNJ DVZ EZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
3 gm/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
-
REFERENCE :
-
YKKKA8 Yakugaku Kenkyu. Japanese Journal of Pharmacy and Chemistry. (Osaka, Japan) V.1-39, 1929-68. Discontinued. Volume(issue)/page/year: 35,94,1963
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
600 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
-
REFERENCE :
-
YKKKA8 Yakugaku Kenkyu. Japanese Journal of Pharmacy and Chemistry. (Osaka, Japan) V.1-39, 1929-68. Discontinued. Volume(issue)/page/year: 35,94,1963
|
【方法一】
4-氨基-5-咪唑羟酰胺-水合物与乳清酸成盐而得。取14.4g4-氨基-5-咪唑羟酰胺单水合物和17.4g乳清酸单水合物加热溶于600ml水中，溶液用活性炭脱色，冷却，然后过滤，得28g白色结晶性阿卡明。
