423165-07-5

• 常用中文名：(1R,3s,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷
• 常用英文名：(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo3.2.1octane
• CAS号：423165-07-5
• 分子式：C₁₃H₂₂N₄
• 分子量：234.341
• 发布时间：2018-12-05 14:42:17
• 更新时间：2026-06-30 12:13:40

名称

• 中文名: (1R,3s,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷
• 英文名: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
• 中文别名: 马拉维诺中间体1 (1R,3S,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.6]辛烷; 马拉维诺中间体1; 外型-3-[3-甲基-5-异丙基-4H-1,2,4-三氮唑]-8-氮杂双环[3,2,1]辛烷; 马拉维若中间体; 马拉维若中间体2; 3-[3-甲基-5-异丙基-4H-1,2,4-三氮唑]-8-氮杂双环[3,2,1]辛烷; (1R,3S,5S)-REL-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷; (1R,3S,5S)-3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷
• 英文别名: (3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane; (3-Exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl] -8-Azabicyclo[3.2.1]octane; (3-exo)-3-[3-Methyl-5-(prop-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane, 4-[(3-exo)-8-Azabicyclo[3.2.1]oct-3-yl]-3-isopropyl-5-methyl-4H-1,2,4-triazole; 3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]octane; (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8; (3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane; Des[1-(4,4-difluorocyclohexanecboxamido)-1-phenylpropyl] Maviroc; Maviroc Intermediate 2; exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane; 3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane; Maviroc Impurity : (3-exo)-3-[3-Methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane; Maviroc interMediate(Tropinone); 8-Azabicyclo[3,2,1]octane3-[3-methyl-5-(1-methlethyl)-4H-1,2,4-triazol-4-yl]-, (3-exo); (1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane; (1R,3s,5S)-rel-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane; 8-Azabicyclo[3.2.1]octane, 3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-, (3-exo)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 402.4±55.0 °C at 760 mmHg
• 熔点: 117ºC
• 分子式: C₁₃H₂₂N₄
• 分子量: 234.341
• 闪点: 197.1±31.5 °C
• 精确质量: 234.184448
• PSA: 42.74000
• LogP: 1.14
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.678
• 储存条件: 2-8°C，避光，保存于惰性气体中

合成路线

423165-13-3 ~99% 423165-07-5

文献：WO2008/63600 A2, ; Page/Page column 11-12; 28 ; WO 2008/063600 A2

76272-34-9 ~% 423165-07-5

文献：US2011/251192 A1, ; US 20110251192 A1

542-05-2 ~% 423165-07-5

文献：US2011/251192 A1, ; US 20110251192 A1

28957-72-4 ~% 423165-07-5

文献：US2011/251192 A1, ; US 20110251192 A1

76272-36-1 ~% 423165-07-5

文献：US2011/251192 A1, ; US 20110251192 A1

376348-67-3 ~% 423165-07-5

文献：US2011/251192 A1, ; US 20110251192 A1

上下游产品

上游产品  6
423165-13-3 76272-34-9 542-05-2 28957-72-4
76272-36-1 376348-67-3
下游产品  2
376348-70-8 376348-65-1