CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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OK6690000
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CHEMICAL NAME :
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Luteinizing hormone-releasing hormone (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl- L-prolinamide)-10-deglycinamide-
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CAS REGISTRY NUMBER :
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57982-77-1
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LAST UPDATED :
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199610
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DATA ITEMS CITED :
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23
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MOLECULAR FORMULA :
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C60-H86-N16-O13
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MOLECULAR WEIGHT :
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1239.62
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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1620 ug/kg/13W-I
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TOXIC EFFECTS :
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Vascular - BP elevation not characterized in autonomic section
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REFERENCE :
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BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 294,1101,1987 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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1080 ug/kg
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SEX/DURATION :
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female 90 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - other measures of fertility
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REFERENCE :
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LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,215,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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6960 ng/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - other effects
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 19,497,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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129 ug/kg
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SEX/DURATION :
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female 37 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 19,497,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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144 ug/kg
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SEX/DURATION :
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female 12 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 22,287,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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1456 ug/kg
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SEX/DURATION :
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female 26 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects Reproductive - Fertility - other measures of fertility
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,187,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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1456 ug/kg
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SEX/DURATION :
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female 26 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,187,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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8500 ug/kg
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SEX/DURATION :
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male 17 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male
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REFERENCE :
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ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 91,601,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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2200 ng/kg
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SEX/DURATION :
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female 22 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects Reproductive - Fertility - other measures of fertility
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 17,537,1978
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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100 ng/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - menstrual cycle changes or disorders
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 25,31,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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2800 ng/kg
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SEX/DURATION :
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female 14 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 21,191,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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8 ug/kg
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SEX/DURATION :
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male 8 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 25,213,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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70 ug/kg
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SEX/DURATION :
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male 28 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 25,213,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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560 ng/kg
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SEX/DURATION :
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male 28 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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REFERENCE :
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ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 94,489,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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80 ug/kg
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SEX/DURATION :
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female 28-31 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - other measures of fertility
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REFERENCE :
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FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 39,218,1983
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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30 ug/kg
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SEX/DURATION :
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male 60 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - impotence Reproductive - Effects on Newborn - biochemical and metabolic
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 43,187,1991
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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15 ug/kg
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SEX/DURATION :
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male 30 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
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REFERENCE :
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CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 43,187,1991
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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840 ug/kg
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SEX/DURATION :
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male 15 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
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REFERENCE :
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ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 22,567,1990
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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DOSE :
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12500 ng/kg
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SEX/DURATION :
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male 5 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male Endocrine - aldosteronism
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REFERENCE :
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IJANDP International Journal of Andrology. (Scriptor Publisher ApS, 15 Gasvaerksvej, DK-1656 Copenhagen V, Denmark) V.1- 1978- Volume(issue)/page/year: 5,607,1982
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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16 ug/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - menstrual cycle changes or disorders
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REFERENCE :
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JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 70,1904,1992
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Implant
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DOSE :
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25 ug/kg
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SEX/DURATION :
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female 70 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Maternal Effects - other effects Endocrine - changes in luteinizing hormone
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REFERENCE :
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JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 141,317,1994
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Implant
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DOSE :
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25 ug/kg
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SEX/DURATION :
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female 10-16 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - endocrine system
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REFERENCE :
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JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 96,785,1992
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Implant
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DOSE :
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86400 ug/kg
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SEX/DURATION :
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male 72 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male
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REFERENCE :
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JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 80,257,1987
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