103335-41-7

• 常用中文名：非那雄胺中间体
• 常用英文名：Methyl 3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxylate
• CAS号：103335-41-7
• 分子式：C₂₀H₂₉NO₃
• 分子量：331.449
• 发布时间：2019-01-01 20:06:43
• 更新时间：2026-09-01 11:35:12

名称

• 中文名: 4-氮杂-5alpha-雄甾-1-烯-3-酮-17beta-羧酸甲酯
• 英文名: methyl (1S,3aS,3bS,5aR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxylate
• 中文别名: 非那雄胺杂质B; 非那雄胺甲酯类似物; 非那雄胺杂质2(非那雄胺杂质B); 度他雄胺酯杂质(非那雄胺杂质B); 4-氮杂-5Α-雄甾-1-烯-3-酮-17Β-甲酸甲酯; 3-氧代-4-氮杂-5alpha-雄甾-1-烯-17beta-羧酸甲酯; 非那雄胺杂质B(度他雄胺酯杂质); (4,4BS,6AS,7S,9AS,9BS,11-甲基4A,6A-二甲基-2-氧代-2,4A,4B,5,6,6A,7,8,9,9A,9B,10,11,11A-十四氢-1H-茚并[5,4-F]喹啉-7-羧酸盐 (度他雄胺杂质); (4,4BS,6AS,7S,9AS,9BS,11-4A,6A-二甲基-2-氧代-2,4A,4B,5,6,6A,7,8,9,9A,9B,10,11,11A-十四氢-1H-茚并[5,4-F]喹啉-7-羧酸甲酯; 非那雄胺杂质B(度他雄胺杂质11); 非那雄胺杂质3; 度他雄胺M4甲酯; 菲那雄胺杂质; 4-氮杂-5ALPHA-雄甾-1-烯-3-酮-17BETA-羧酸甲酯; 非那雄胺杂质III对照品; M4甲酯; 4-氮杂-5Α-雄甾-1-烯-3-酮-17Β-羧酸甲酯; 非那雄胺相关化合物D; 非那雄胺杂质B 标准品; 化合物 (4,4BS,6AS,7S,9AS,9BS,11-METHYL 4A,6A-DIMETHYL-2-OXO-2,4A,4B,5,6,6A,7,8,9,9A,9B,10,11,11A-TETRADECAHYDRO-1H-INDENO[5,4-F]QUINOLINE-7-CBOXYLATE; 3-氧代-4-氮杂-5ALPHA-雄甾-1-烯-17BETA-羧酸甲酯
• 英文别名: Finasteride Impurity 2（Finasteride Impurity B）; Finasteride Impurity B(Dutasteride Impurity 11); Dutasteride Related Impurity 4; Dutasteride Impurity 3; 3-Oxo-4-aza-5α-αndrost-1-ene-17β-cboxylic Acid Methyl Ester; methyl-3- oxo-4-aza-5-alfa-androst-1ene-17-beta-cboxylate; Dutasteride Ester Impurity (Finasteride Impurity B); (4,4bS,6aS,7S,9aS,9bS,11-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7, 8,9,9a,9b,10,11,11a-t; Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-cboxylate（M4）; (4,4bS,6aS,7S,9aS,9bS,11); Methyl 4-aza-5alpha-Androsta-1-en-3-one-17beta-Carboxylate; methyl 3-oxo-4-aza-5α-androst-1-ene-17β-cboxylate; Finasteride Impurity B; methyl (4,4bS,6aS,7S,9aS,9bS,11-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-cboxylate; Dutasteride Methyl Ester Impurity; Methyl 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-cboxylate (Delta-1-Aza Ester); (4aR,4bS,6aS,7S,9aS,9bS,11aR)-methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate; Finasteride Impurity B (Dutasteride Ester Impurity); (4,4bS,6aS,7S,9aS,9bS,11-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-cboxylate; Methyl (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate; 1H-Indeno[5,4-f]quinoline-7-cboxylic acid, 2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, methyl ester, (4,4bS,6aS,7S,9aS,9bS,11); Methyl 3-Oxo-4-aza-5alpha-androst-1; Finasteride Impurity B / Finasteride Related Compound D / Dutasteride Methyl Ester Impurity / Dutasteride MethylEsterAnalog; 3-Oxo-4-aza-5Alpha-Alphandrost-1-ene-17Beta-carboxylic Acid Methyl Ester; Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-cboxylate; 3-Oxo-4-aza-5α-αndrost-1-ene-173-cboxylic acid methyl ester; Dutasteride Methyl Ester Analog (Finasteride Methyl Ester Analog); (4,4bS,6aS,7S,9aS,9bS,11-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-cboxylate (Dutasteride Impurity); Finasteride Methyl Ester Analog; (4,4bS,6aS,7S,9aS,9bS,11-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a; 3-Oxo-4-azα-5α-androst-1-ene-17β-cboxylic Acid Methyl Ester; METHYL 4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CBOXAMIDE(M4); Methyl 3-oxo-4-aza-5a-androst-1-ene-17beta-carboxylate; Methyl 4-aza-5a-Androsta-1-en-3-one-17b-Carboxylate; Finasteride Impurity B/ Finasteride Related Compund D (Dutasteride Methyl Ester Analog/Finasteride Methyl Ester Analog); (4,4bS,6aS,7S,9aS,9bS,11-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-Tetradecahydro-4a,6a-diMethyl-2-oxo; methyl (1S,3aS,3bS,5,9,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-cboxylate; METHYL 3-OXO-4-AZA-5-ALPHA-ANDROST-1-ENE-17-BETA-CBOXYLATE

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 478.6±45.0 °C at 760 mmHg
• 熔点: 280-282ºC (dec.)
• 分子式: C₂₀H₂₉NO₃
• 分子量: 331.449
• 闪点: 243.3±28.7 °C
• 精确质量: 331.214752
• PSA: 55.40000
• LogP: 3.24
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.525
• 储存条件: 2-8°C，干燥

合成路线

73671-92-8 ~% 103335-41-7

文献：Journal of the American Chemical Society, , vol. 110, # 10 p. 3318 - 3319

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