CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UP0745000
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CHEMICAL NAME :
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9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-
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CAS REGISTRY NUMBER :
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2133-81-5
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LAST UPDATED :
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199703
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C10-H13-N5-O3-S
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MOLECULAR WEIGHT :
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283.34
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WISWESSER LINE NOTATION :
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T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1 gm/kg/5D-I
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1500 mg/kg/33D-I
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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3 gm/kg/5D-I
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)
MUTATION DATA
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TYPE OF TEST :
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Host-mediated assay
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TEST SYSTEM :
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Rodent - mouse Cells - not otherwise specified
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DOSE/DURATION :
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100 umol/kg
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REFERENCE :
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CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,1103,1975
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