186204-37-5

• 常用中文名：(3aR,7aR)-4'-(1,2-苯并异噻唑-3-基)八氢螺[2H-异吲哚-2,1'-哌嗪]甲磺酸盐
• 常用英文名：Lurasidone Impurity 14
• CAS号：186204-37-5
• 分子式：C₂₀H₂₉N₃O₃S₂
• 分子量：423.6
• 发布时间：2018-12-24 17:15:43
• 更新时间：2026-10-29 15:42:55

名称

• 中文名: (3AR,7AR)-4’-(1,2-苯并异噻唑-3-基)八氢螺[2H-异吲哚-2,1’-哌嗪]甲磺酸盐
• 英文名: 4-(1,2-Benzothiazol-3-yl)-1-[(3aR,7aR)-octahydro-2H-isoindol-2-yl ]piperazin-1-ium-1-sulfonate
• 中文别名: 负一步中间体; (3,7 -4'-(苯并[ D ]异噻唑 -3-基)八氢螺旋[异吲哚 -2,1'-哌嗪] -2-甲基磺酸铵; (3,7-4'-(1,2-苯并异噻唑-3-基)八氢螺[2H-异吲哚-2,1'-哌嗪]甲磺酸盐; (3,7-4'-(苯并[D]异噻唑-3-基)十氢螺环螺[异吲哚-2,1'-吡嗪]-2-鎓甲磺酸盐; 4'-(1,2-苯并异噻唑-3-基)-(3,7-八氢-螺[2H-异吲哚-2,1'-哌嗪]-1'-鎓甲磺酸盐; 鲁拉西酮杂质41甲磺酸盐; (3,7-4'-(1,2-苯并异噻唑-3-基)八氢螺[2H-异吲哚-2,1'-哌嗪]甲磺酸; 卢拉西酮杂质34; 鲁拉西酮杂质11; 鲁拉西酮哌嗪杂质; (3,7-4'-(1,2-苯并异噻唑-3-基)八氢螺[2H-异吲哚-2,1'-哌嗪]甲磺酸盐 4-(1,2-BENZOTHIAZOL-3-YL)-1-[(3,7-OCTAHYDRO-2H-ISOINDOL-2-YL]PIPERAZIN-1-IUM-1-SULFONATE; (3,7-4'-(苯并[D]异噻唑-3-基)八氢螺[异吲哚-2,1'-哌嗪]-2-鎓 甲磺酸盐
• 英文别名: 4'-(1,2-benzisothiazol-3-yl)-(3aR,7aR)-octahydro-spiro[2H-isoindole-2,1'-piperazin]-1'-ium methanesulfonate; (3,7-4'-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1'-piperazinium] methanesulfonate; 3-(4-methylstyryl)-pyridine; Lurasidone Impurity 34; piperazin]-1'; 4'-(1,2-benzisothiazol-3-yl)-(3aR,7aR)-octahydro-spiro[2H-isoindole-2,1'-piperazinium]methanesulfonate; [3AR,7AR]-4-[1,2 BENZISOTHIAZOL-3-YL]OCTAHYDROSPIRO[2H-ISOINDOLE-2,1-PIPERAZINIUM] METHANESULFONATE; 3-(4-Methylstyryl)pyridin; (3,7), octahydro-[2H-isoindole-2-spiro-1'-piperazinium], 4'-(1,2-benzisothiazol-3-yl), methanesulfonate (1:1); (3,7-4'-(Benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate; piperazinium]Methanesulfonate; Lurasidone Impurity 41 Mesylate; (3,7-4’ (3,7-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole- 2,1'-piperazin]-2-ium methanesulfonate; 4-(1,2-Benzothiazol-3-yl)-1-[(3aR,7aR)-octahydro-2H-isoindol-2-yl]piperazin-1-ium-1-sulfonate; trans-3a,7a-octahydroisoindolium-2-spiro-1'-[4-(1,2-benzisothiazol-3-yl)]piperazine methanesulfonate; lurasidone-8; ium methanesulfonate; Piperazinium, 4-(1,2-benzisothiazol-3-yl)-1-[(3aR,7aR)-octahydro-2H-isoindol-2-yl]-1-sulfo-, inner salt; (3,7-4'-(1,2-benzisothiazol-3-yl)octahydro-Spiro[2H-isoindole-2,1'-piperazinium] methanesulfonate (1:1); (1,2-Benzisothiazol-3-yl)octahydro-spiro[2H-isoindole-2,1’ (3,7-4'-(Benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-1'-ium methanesulfonate; (3,7-4'-(1,2-BENZISOTHIAZOL-3-YL)OCTAHYDROSPIRO[2H-ISO-INDOLE-2,1'-PIPERAZINIUM] METHAN SULFONATE; (3,7-4'-(Benzo[d]isothiazol-3-yl)octahydro-spiro[2H-isoindol-2,1'-piperazinium] mesylate; trans-R,R-3a,7a-octahydroisoindolium-2-spiro-1'-[4'-(1,2-benzoisothiazol-3-yl)]piperazine methanesulfonate; trans-(R,R)-3a,7a-octahydroisoindolium-2-spiro-1'-[4'-(1,2-benzoisothiazole-3-yl)]piperazine methane sulfonate; C19H26N3S.CH3O3S (3,7-4'-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1'-piperaziniuM] Methanesulfonate 186-5; Spiro[2H-isoindole-2,1'-piperazinium], 4'-(1,2-benzisothiazol-3-yl)octahydro-, (3,7)-, methanesulfonate (1:1); 4-(1,2-Benzothiazol-3-yl)-1-[(3,7-octahydro-2H-isoindol-2-yl]piperazin-1-ium-1-sulfonate; Pyridine,trans-3-[2-(4-methylphenyl)ethenyl]; (3,7-4'-(benzo[d]isothiazol-3-yl); 4-(Benzo[d]isothiazol-3-yl)-1-((3,7-hexahydro-1H-isoindol-2(3H)-yl)piperazin-1-iuM-1-sulfonate; (3aR,7aR)-4'-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1'-piperazinium]methanesulfonate; (3,7-4'-(1,2-Benzisothiazol-3-yl) octahydro-spiro[2H-isoindole-2,1'-piperazinium] methanesulfon; trans-4'-Methyl-3-stilbazol; trans-3-(4-Methyl-styryl)-pyridin; Lurasidone impurity 17/(3,7-4-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1-piperaziniuM] Methanesulfonate; 4-(1,2-Benzothiazol-3-yl)-1-[(3,7-octahydro-2H-isoindol; Lurasidone Impurity 34 Mesylate; (3,7-4'-(1,2-Benzisothiazol-3-yl)octahydro-spiro[2H-isoindole-2,1'-piperazinium] Methanesulfonate; (E)-3-[2-(4-Methylphenyl)ethenylpyridine; (R,R)-3a,7a-octahydroisoindolium-2-spiro-1'-[4'-(1,2-benzoisothiazole-3-yl)]piperazine methanesulfonate

物化性质

• 分子式: C₂₀H₂₉N₃O₃S₂
• 分子量: 423.6
• 精确质量: 423.16503414
• PSA: 113.19000
• LogP: 3.47280
• 储存条件: 2-8℃

合成路线

186204-35-3 87691-87-0 ~87% 186204-37-5

文献：SHASUN PHARMACEUTICALS LIMITED; VIJAYABASKAR, V.; SRIMURUGAN, S.; KUMAR, R.V. Sathish; JAYAMANI, Munusamy Patent: WO2013/190455 A2, 2013 ; Location in patent: Page/Page column 13; 14 ;

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