135705-03-2

• 常用中文名：1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione
• 常用英文名：1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione
• CAS号：135705-03-2
• 分子式：C₁₆H₁₉N₅O₂
• 分子量：313.35400
• 发布时间：2016-05-13 15:17:04
• 更新时间：2024-01-14 15:52:53

名称

• 英文名: 1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)but-2-ynyl]pyrrolidine-2,5-dione
• 英文别名: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione,1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-2-butynyl)

物化性质

• 密度: 1.295g/cm3
• 沸点: 582.4ºC at 760mmHg
• 分子式: C₁₆H₁₉N₅O₂
• 分子量: 313.35400
• 闪点: 306ºC
• 精确质量: 313.15400
• PSA: 69.64000
• 蒸汽压: 1.49E-13mmHg at 25°C
• 折射率: 1.603

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UY1032500 CHEMICAL NAME : 2,5-Pyrrolidinedione, 1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)-2-butynyl)- CAS REGISTRY NUMBER : 135705-03-2 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H19-N5-O2 MOLECULAR WEIGHT : 313.40 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 257 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,193,1991

合成路线

50-00-0 20980-22-7 10478-33-8 ~76% 135705-03-2

文献：Komissarov, I. V.; Kharin, N. A.; Voshula, V. N.; Tolkunov, S. V.; Kibal'nyi, A. V.; et al. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 3 p. 193 - 196 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 3 p. 40 - 42

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