13479-38-4

• 常用中文名：17-脱羟基泼尼松龙-d8
• 常用英文名：(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
• CAS号：13479-38-4
• 分子式：C₂₁H₂₈O₄
• 分子量：344.44500
• 发布时间：2016-09-19 13:08:08
• 更新时间：2026-08-01 20:24:26

名称

• 中文名: 17-脱羟基泼尼松龙-d8
• 英文名: (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
• 中文别名: 17-脱氧泼尼松龙; 泼尼松杂质I(17脱氧泼尼松); (8S,9S,10R,11S,13S,14S,17S)-11-羟基-17-(2-羟基乙酰基)-10,13-二甲基-6,7,8,9,10,11,12,13, 14,15,16,17-十二氢-3H-环戊烷; (8S,9S,10R,11S,13S,14S,17S)-11-羟基-17-(2-羟基乙酰基)-10,13-二甲基-6,7,8,9,10,11,12,13, 14,15,16,17-十二氢-3H-环戊烷[A]菲-3-酮 (泼尼松龙杂质); 泼尼松龙杂质22; 泼尼松龙杂质9(泼尼松龙杂质I); 泼尼松龙杂质I; 泼尼松龙杂质9; 地奈德杂质I对照品
• 英文别名: (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (Prednisolone Impurity); Prednisolone Impurity I (17-Deoxy Prednisolone); 1-Dehydrocorticosterone; Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-, (11β); 11,21-Dihydroxypregna-1,4-diene-3,20-dione (11beta); 17-Dehydroxy Prednisolone; Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-,(11beta); 11β,21-Dihydroxypregna-1,4-diene-3,20-dione (17-Desoxyprednisolone); Prednisolone Impurity 9（Prednisolone Impurity I）; 17-Deoxyprednisolone; 11β,21-Dihydroxy-pregn-1,4-diene-3,20-dione; 1, 4-PREGNADIEN-11β, 21-DIOL-3, 20-DIONE; 2a3i; Prednisolone Impurity I; (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

物化性质

• 密度: 1.241g/cm3
• 沸点: 532.789ºC at 760 mmHg
• 分子式: C₂₁H₂₈O₄
• 分子量: 344.44500
• 闪点: 290.094ºC
• 精确质量: 344.19900
• PSA: 74.60000
• LogP: 2.44270
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.592

合成路线

50-24-8 ~77% 13479-38-4

文献：Numazawa; Nagaoka; Kunitama Chemical and pharmaceutical bulletin, 1986 , vol. 34, # 9 p. 3722 - 3726

50-22-6 ~% 13479-38-4

文献：Nobile et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 4184 Full Text View citing articles Show Details Herzog et al. Tetrahedron, 1962 , vol. 18, p. 581,588

110247-37-5 ~% 13479-38-4

文献：Schering Corp. Patent: US2767155 , 1954 ;