160514-13-6

• 常用中文名：氯沙坦钾杂质 B
• 常用英文名：(2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol
• CAS号：160514-13-6
• 分子式：C₁₄H₁₂N₄O
• 分子量：252.271
• 发布时间：2018-09-22 13:02:19
• 更新时间：2026-07-22 19:31:05

名称

• 中文名: 2'-(2H-四唑-5-基)-[1,1'-联苯]-4-甲醇
• 英文名: 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]methanol
• 中文别名: A厄贝沙坦杂质7; 洛沙坦杂质2(洛沙坦杂质B); (2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲醇 (氯沙坦杂质); 氯沙坦杂质B(奥美沙坦酯杂质); 氯沙坦欧洲药典杂质 B; 氯沙坦钾杂质B; 氯沙坦杂质B(厄贝沙坦杂质2); 洛沙坦杂质B 标准品; (2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲醇; 缬沙坦杂质(4'- 羟甲基联苯四氮唑); 阿利沙坦酯杂质G; 氯沙坦杂质B
• 英文别名: Lostan Potassium Impurity B; [4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methanol; Irbestan Hydroxy Impurity Candestan Hydroxy Impurity; 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol; Lostan IMpurity B; [2'-(2H-Tetrazol-5-yl)-4-biphenylyl]methanol; Lostan IMpurity B (Lostan HydroxyIMpurity ); [2'-(1H-Tetrazol-5-yl)biphenyl-4-yl; 2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol; Allistan Isoproxil impurity G; [1,1'-Biphenyl]-4-methanol, 2'-(2H-tetrazol-5-yl); 2'-(1H-Tetrazol-5-yl); (2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol (Lostan Impurity); 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-methanol; Irbestan Hydroxy Impurity (Candestan Hydroxy Impurity/ Lostan Hydroxy Impurity/ Lostan Impurity B); Lostan Impurity 2(Lostan Impurity B); (2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methanol; Lostan Impurity B (Lostan Hydroxy Impurity/ Irbestan Hydroxy Impurity/ Candestan Hydroxy Impurity); Lostan Impurity B(Irbestan Impurity 2); Candestan Hydroxy Impurity (Irbestan Hydroxy Impurity/ Lostan Hydroxy Impurity/ Lostan Impurity B)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 527.6±60.0 °C at 760 mmHg
• 分子式: C₁₄H₁₂N₄O
• 分子量: 252.271
• 闪点: 272.9±32.9 °C
• 精确质量: 252.101105
• PSA: 74.69000
• LogP: 1.92
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.657

合成路线

154709-19-0 ~% 160514-13-6

文献：NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2005/14602 A1, 2005 ; Location in patent: Page/Page column 42-43 ;

862802-05-9 ~% 160514-13-6

文献：NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2005/75462 A1, 2005 ; Location in patent: Page/Page column 26 ; WO 2005/075462 A1

73096-42-1 59016-93-2 ~53% 160514-13-6 18039-42-4

文献：Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit Tetrahedron Letters, 2005 , vol. 46, # 38 p. 6529 - 6532

73096-42-1 59016-93-2 ~% 160514-13-6

文献：Cousaert, Nicolas; Willand, Nicolas; Gesquiere, Jean-Claude; Tartar, Andre; Deprez, Benoit; Deprez-Poulain, Rebecca Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2743 - 2747