70381-75-8

• 常用中文名：5,6-二氯-3,4-二氢-2(1H)-亚胺喹唑啉-3-乙酸乙酯氢溴酸盐
• 常用英文名：Ethyl-5,6-dichloro-3,4-dihydro-2(1H)imino quinazoline-3-acetate hydrobromide
• CAS号：70381-75-8
• 分子式：C₁₂H₁₄BrCl₂N₃O₂
• 分子量：383.069
• 发布时间：2018-12-18 07:01:23
• 更新时间：2024-01-01 18:59:04

名称

• 中文名: 5,6-二氯-3,4-二氢-2(1H)-亚胺喹唑啉-3-乙酸乙酯氢溴酸盐
• 英文名: ethyl 2-(2-amino-5,6-dichloro-4H-quinazolin-3-yl)acetate,hydrobromide
• 中文别名: 5,6-二氯-3,4-二氢-2(1H)亚胺喹唑啉-3-乙酸乙酯氢溴酸盐
• 英文别名: 3(2H)-quinazolineacetic acid, 5,6-dichloro-1,4-dihydro-2-imino-, ethyl ester, hydrobromide (1:1); 3(4H)-Quinazolineacetic acid, 2-amino-5,6-dichloro-, ethyl ester, hydrobromide (1:1); Ethyl (5,6-dichloro-2-imino-1,4-dihydroquinazolin-3(2H)-yl)acetate hydrobromide (1:1); Ethyl (2-amino-5,6-dichloro-3(4H)-quinazolinyl)acetate hydrobromide (1:1)

物化性质

• 沸点: 459.7ºC at 760 mmHg
• 分子式: C₁₂H₁₄BrCl₂N₃O₂
• 分子量: 383.069
• 精确质量: 380.964630
• PSA: 65.42000
• LogP: 3.85250

MSDS

Name: Ethyl 5 6-dichloro-dihydro-2(1H)-iminoquinazoline-3-acetate Material Safety Data Sheet Synonym: Ethyl 2-amino-5,6-dichloro-3(4H)-quinazolineacetate hydrobromid CAS: 70381-75-8 Section 1 - Chemical Product MSDS Name:Ethyl 5 6-dichloro-dihydro-2(1H)-iminoquinazoline-3-acetate Material Safety Data Sheet Synonym:Ethyl 2-amino-5,6-dichloro-3(4H)-quinazolineacetate hydrobromid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 70381-75-8 Ethyl 5,6-dichloro-dihydro-2(1H)-imino unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 70381-75-8: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 280 deg C(decom) Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H13Cl2N3O2.HBr Molecular Weight: 383.07 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 70381-75-8 unlisted. LD50/LC50: Not available. Carcinogenicity: Ethyl 5,6-dichloro-dihydro-2(1H)-iminoquinazoline-3-acetate hydrobromide - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 70381-75-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 70381-75-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 70381-75-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

506-68-3 70406-92-7 ~% 70381-75-8

文献：WO2008/96145 A1, ; Page/Page column 13-14 ;