143322-56-9

• 常用中文名：R-3-(N-苄氧基羰基吡咯烷-2-基羰基)-5-溴-1H-吲哚
• 常用英文名：(r)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1h-indole
• CAS号：143322-56-9
• 分子式：C₂₁H₁₉BrN₂O₃
• 分子量：427.29100
• 发布时间：2019-01-01 11:26:48
• 更新时间：2024-01-08 10:29:00

名称

• 中文名: (R)-2-[(5-溴-1H-吲哚-3-基)羰基]-1-吡咯烷甲酸苄酯
• 英文名: (R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate
• 中文别名: 依利曲坦中间体
• 英文别名: (R)-2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester; InterMediate of Eletriptan; benzyl (2R)-2-[(5-bromo-1H-indole-3-yl)carbonyl]pyrrolidine-1-carboxylate; (R)-2-(5-bomo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester; (R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylcarbonyl)-5-bromo-1H-indole; (R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole; (R)-2-[(5-Bromo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic acid benzyl ester; (2R)-2-[(5-BroMo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic Acid PhenylMethyl Ester; (R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate; 3-(N-benzyloxycarbonylpyrrolidin-2R-ylcarbonyl)-5-bromo-1H-indole

物化性质

• 密度: 1.505
• 沸点: 605ºC at 760 mmHg
• 分子式: C₂₁H₁₉BrN₂O₃
• 分子量: 427.29100
• 闪点: 319.7ºC
• 精确质量: 426.05800
• PSA: 62.40000
• LogP: 4.85220
• 外观性状: 白色固体
• 蒸汽压: 1.38E-14mmHg at 25°C
• 折射率: 1.678
• 储存条件: 2-8°C，干燥密封

安全

• 海关编码: 2933990090

合成路线

10075-50-0 61350-62-7 ~72% 143322-56-9

文献：Slassi, Abdelmalik; Meng, Charles Q.; Dyne, Kerry; Wang, Xin; Lee, David K. H.; Kamboj, Rajender; McCallum, Kirk L.; Mazzocco, Lucy; Rakhit, Suman Medicinal Chemistry Research, 1999 , vol. 9, # 9 p. 668 - 674

10075-50-0 144-55-8 61350-62-7 ~72% 143322-56-9

文献：NPS Allelix Corp. Patent: EP944595 B1, 2003 ; Location in patent: Page/Page column 13 ; EP 0944595 B1

10075-50-0 676-58-4 61350-62-7 ~% 143322-56-9

文献：WO2010/121673 A1, ; Page/Page column 16-17 ;

10075-50-0 79-37-8 925-90-6 61350-62-7 6404-31-5 详细

文献：US5545644 A1, ; US 5545644 A US5559129 A1, ; US 5559129 A US5559246 A1, ; US 5559246 A US5578612 A1, ; US 5578612 A US5607951 A1, ; US 5607951 A

10075-50-0 925-90-6 144-55-8 61350-62-7 ~% 详细

文献：US5545644 A1, ; US 5545644 A

6404-31-5 ~% 143322-56-9

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3419 - 3421

上下游产品

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%