188416-35-5

• 常用中文名：外消旋-6-氯 伏立康唑
• 常用英文名：rac-6-Chloro Voriconazole
• CAS号：188416-35-5
• 分子式：C₁₆H₁₄Cl₂F₃N₅O
• 分子量：420.216
• 发布时间：2018-12-07 19:44:18
• 更新时间：2024-01-04 09:04:21
• 【用途一】
  伏立康唑中间体5

名称

• 中文名: (2R,3S/2S,3R)-3-(6-氯-5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇
• 英文名: rac-6-Chloro Voriconazole
• 中文别名: (2R,3S/2S,3R)-3-(4-氯-5-氟-6-嘧啶基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇盐酸盐; 3-(6-氯-5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇; 伏立康唑中间体一; 外消旋-6-氯 伏立康唑
• 英文别名: 4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αS,βR)-, hydrochloride (1:1); Vfend; MFCD07772028; (2R,3S)-2-(2,4-Difluorphenyl)-3-(5-fluorpyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (R-(R*,S*))-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; 4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol; (2S,3R)-3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride (1:1); 3-(6-Chlor-5-fluorpyrimidin-4-yl)-2-(2,4-difluorphenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol,hydrochloride; (2S,3R)-3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride; 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; Voriconazole; (2R,3S)-2-(2,4-difluorophényl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; Vorionazole; 3-(6-Chloro-5-fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol; (aR,bS)-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; 3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol; (2R.3S/2S.3R) -3-(4-CHLORO-5-FLUOROPYRIMIDIN-6-YL)-2 -(2,4-D IFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL) BUTAN-2-OL HYDROCHL; Voriconazole Impurity 9

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 529.9±60.0 °C at 760 mmHg
• 熔点: 183-187°C
• 分子式: C₁₆H₁₄Cl₂F₃N₅O
• 分子量: 420.216
• 闪点: 274.2±32.9 °C
• 精确质量: 419.052765
• PSA: 76.72000
• LogP: 1.84
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.629
• 储存条件: Refrigerator

安全

• 海关编码: 2933599090

合成路线

86404-63-9 137234-74-3 ~27% 188416-35-5

文献：DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC. Patent: WO2006/65726 A2, 2006 ; Location in patent: Page/Page column 17-18 ;

86404-63-9 ~% 188416-35-5

文献：US5278175 A1, ;

137234-87-8 ~% 188416-35-5

文献：US2011/312977 A1, ;

上下游产品

上游产品  3
86404-63-9 137234-74-3 137234-87-8
下游产品  2
137234-62-9 182230-43-9

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%